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MetabolomicsAirway Dysbiosis Accelerates Lung Function Decline in Chronic Obstructive Pulmonary Disease (Human UPLC-MS/MS assays)

Progressive decline in lung function is a hallmark of chronic obstructive pulmonary disease (COPD). Although airway dysbiosis occurs in COPD, whether it contributes to disease progression remains unknown. Here, through a longitudinal analysis on 181 COPD individuals from two large cohorts involvi...

2023-06-12 | MTBLS5423 | MetaboLights
MetabolomicsAirway Dysbiosis Accelerates Lung Function Decline in Chronic Obstructive Pulmonary Disease (Murine UPLC-MS/MS assays)

Progressive lung function decline is a hallmark of chronic obstructive pulmonary disease (COPD). Airway dysbiosis occurs in COPD, but whether it contributes to disease progression remains unknown. Here we showed, through a longitudinal analysis on two cohorts involving four UK centers, that basel...

2023-06-12 | MTBLS6894 | MetaboLights
ProteomicsProteomic and transcriptomic analysis of Allium mongolicum seeds
Seeds, as an effective depository of plant genetic resources and an important raw material for germplasm innovation, aging or deterioration will directly lead to a reduction in germination rate, vigor and viability, inhibit the normal development of the seed embryo and seedling growth. Methods: Alli...
ORGANISM(S): Allium Mongolicum 
2024-11-18 | PXD058020 |
ProteomicsRAN, TDP43 and G3BP1 mRNA form a complex
To identify the candidate that directly stabilizes G3BP1 mRNA, the enriched proteins pulled down by G3BP1 probes and anti-RAN antibody were subjected to mass spectrometry (MS) analysis
ORGANISM(S): Homo Sapiens 
PXD056577 |
ProteomicsDelaying aging and enhancing repair of the aged CNS myelin by β-NMN requires SIRT2
Myelin aging is a driving force of CNS aging, and age-dependent declined efficiency of remyelination caused by impaired differentiation capacity of aged oligodendrocyte precursor cell (OPC) is a major cause of demyelinated diseases. Revealing how differentiation capacity of aged OPC is affected meta...
ORGANISM(S): Rattus Norvegicus 
2020-10-18 | PXD022046 |
ProteomicsPan-Cancer Proteogenomic Characterization of Metastatic Brain Tumors
4D-DIA data Derived from Paired Primary Tumors, Brain Metastasis and Giloblastoma
ORGANISM(S): Homo Sapiens 
2025-01-20 | PXD059751 |
MetabolomicsAltered fecal metabolomics and potential biomarkers of psoriatic arthritis differing from rheumatoid arthritis
Psoriatic arthritis (PsA) is a chronic inflammatory joint disease, and the diagnosis is quite difficult due to the unavailability of reliable clinical markers. This study aimed to investigate the fecal metabolites in PsA by comparison with rheumatoid arthritis (RA), and to identify potential diagnos...
2022-02-23 | MTBLS4206 | MetaboLights
ProteomicsMyocardial Mitochondrial Antiviral Signaling Protein Promotes Heart Ischemia-reperfusion Injury via RIG-I Signaling-proteomic sequencing
Myocardial ischemia-reperfusion injury (MIRI) is a life-threatening complication of myocardial infarcts, with inner mitochondrial membrane protein dysfunction involved in MIRI-induced heart injury. The role of outer mitochondrial membrane protein MAVS is unknown. Here we show that MAVS expression in...
ORGANISM(S): Mus Musculus 
2025-03-20 | PXD062097 |
ProteomicsMyocardial Mitochondrial Antiviral Signaling Protein Promotes Heart Ischemia-reperfusion Injury via RIG-I Signaling-mass spectrometry
Myocardial ischemia-reperfusion injury (MIRI) is a life-threatening complication of myocardial infarcts, with inner mitochondrial membrane protein dysfunction involved in MIRI-induced heart injury. The role of outer mitochondrial membrane protein MAVS is unknown. Here we show that MAVS expression in...
ORGANISM(S): Mus Musculus 
2025-03-20 | PXD062096 |
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