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MetabolomicsSalmonella Typhimurium reprograms macrophage metabolism via T3SS effector SopE2 to promote intracellular replication and virulence

Salmonella Typhimurium establishes systemic infection by replicating in host macrophages. Here we show that macrophages infected with S. Typhimurium exhibit upregulated glycolysis and decreased serine synthesis, leading to accumulation of glycolytic intermediates. The effects on...

2024-05-22 | MTBLS2347 | MetaboLights
TranscriptomicsA Comparative Profile of the MicroRNA Transcriptome in Immature and Mature Porcine Testes using Solexa Deep Sequencing
MicroRNAs (miRNAs) are small non-coding regulatory RNAs that play key roles in many diverse biological processes such as spermatogenesis. However, no study has been performed on the miRNA transcriptome of developing porcine testes. Here, we employed Solexa deep sequencing technology to extend the re...
ORGANISM(S): Sus scrofa 
2011-09-23 | E-GEOD-28169 | biostudies-arrayexpress
ProteomicsAeromonas spp MTB Infection May Causally Link to Ulcerative Colitis
Ulcerative colitis (UC) is an inflammatory bowel disease characterized by disruption of the epithelial barrier, and its etiology has long been enigmatic. We here observed a significant depletion of macrophages directly beneath the UC epithelial layer, and hypothesized that this depletion may be caus...
ORGANISM(S): Aeromonas veronii bv. sobria 
2026-03-17 | PXD050471 | Pride
ProteomicsRemoval of antibiotic Thiamphenicol by bacteria Aeromonas hydrophila
Proteomics studies revealed a number of differentially expressed proteins of HS01 in the presence of TAP, which may play critical roles in the transportation and degradation of TAP.
ORGANISM(S): Aeromonas Hydrophila Hs01 
2021-11-17 | PXD029787 |
ProteomicsA causal coding variant regulating alternative splicing of DOC2A at 16p.11.2 GWAS locus influences susceptibility to schizophrenia
Genome-wide association studies (GWASs) have reported numerous genetic variations associated with schizophrenia, but knowledge regarding relevant molecular mechanisms is limited. Many genes undergo sophisticated alternative splicing in the brain, and aberrations of this process may contribute to the...
ORGANISM(S): Mus Musculus 
2025-02-12 | PXD060711 |
ProteomicsSpatial-temporal protein interactome profiling via condensation enhanced crosslinking
MS data for the verification of metabolic incorporation of δ-photolysine, calculation for the crosslinking distance by DegP crosslinking, and the proteomics analysis for the dynamic direct interactome of NPM1 as well as the SG-specific interactomes of SARS-CoV-2 Nucleocapsid protein and YTHDF1/2.
ORGANISM(S): Homo Sapiens Escherichia Coli Severe Acute Respiratory Syndrome Coronavirus 2 
2024-09-11 | PXD052099 |
ProteomicsThe Quartet Data Portal: integration of community-wide resources for multiomics quality control (Proteomics)
The Project aims to provide resources for QC of multiple types of omic technologies and effective integration of diverse datasets from various scenarios. Large quantities of multi-omics materials, datasets, and best practice for their QC utilities were developed for whole process QC of large scale, ...
ORGANISM(S): Homo Sapiens 
2023-09-01 | PXD045065 |
ProteomicsTargeting high circDNA2v levels in colorectal cancer induces cellular senescence and elicits an anti-tumor secretome
The efficacy of immunotherapy against colorectal cancer (CRC) is impaired by insufficient immune cell recruitment into the tumor microenvironment. Our study shows that targeting circDNA2v, a circular RNA commonly overexpressed in CRC, can be exploited to elicit cytotoxic T-cell recruitment. CircDNA2...
ORGANISM(S): Homo Sapiens 
2024-04-11 | PXD051359 |
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