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UnknownBridging systemic metabolic dysfunction and Alzheimer's disease: the liver interface.
Alzheimer's disease (AD) is increasingly recognized as a systemic disorder with a substantial metabolic disorder component, where the liver significantly impacts the brain via the liver-brain axis. Key mechanisms include the liver's role in clearing peripheral β-amyloid (Aβ), the influence of hepati...
S-EPMC12121119 | biostudies-literature
UnknownComparison of Three Algorithms for Predicting Infarct Volume in Patients with Acute Ischemic Stroke by CT Perfusion Software: Bayesian, CSVD, and OSVD.
This study aimed to compare the performance of the Bayesian probabilistic method, circular Singular Value Decomposition (cSVD), and oscillation index Singular Value Decomposition (oSVD) algorithms in Olea Sphere for predicting infarct volume in patients with acute ischemic stroke (AIS). Eighty-seven...
S-EPMC10217375 | biostudies-literature
Unknownm6A regulator-mediated methylation modification patterns and immune microenvironment infiltration characterization in osteoarthritis.
Osteoarthritis (OA) is a common disease in orthopedics. RNA N6-methyladenosine (m6A) exerts an essential effect in a variety of biological processes in the eukaryotes. In this study, we determined the effect of m6A regulators in the OA along with performing the subtype classification. Differential a...
S-EPMC9805027 | biostudies-literature
UnknownQuantitative evaluation of activity of thyroid-associated Ophthalmopathy using short-tau inversion recovery (STIR) sequence.

Objective

Quantitatively staging TAO using MRI remains limited. Our study aims to identify the cut-off signal intensity value for staging TAO using STIR sequence scan.

Methods

Between June 2018 and July 2020, a number of 51 patients with TAO (102 eyes) and 19 volunteer controls (38 ey...
S-EPMC8590769 | biostudies-literature
UnknownNetrin-1 induces the anti-apoptotic and pro-survival effects of B-ALL cells through the Unc5b-MAPK axis.

Background

B-cell acute lymphoblastic leukemia (B-ALL) comprises over 85% of all acute lymphoblastic leukemia (ALL) cases and is the most common childhood malignancy. Although the 5 year overall survival of patients with B-ALL exceeds 90%, patients with relapsed or refractory B-ALL may suffe...
S-EPMC9380321 | biostudies-literature
UnknownPD-L1 mediates M1 polarization of macrophages via the AIM2/IL-18/STAT1 signaling axis during sepsis.
Not available
S-EPMC12817491 | biostudies-literature
UnknownEvaluating the effectiveness of handheld ultrasound in primary blast lung injury: a comprehensive study.
The incidence of blast injuries has been rising globally, particularly affecting the lungs due to their vulnerability. Primary blast lung injury (PBLI) is associated with high morbidity and mortality rates, while early diagnostic methods are limited. With advancements in medical technology, and port...
S-EPMC11742448 | biostudies-literature
UnknownMETTL3/IGF2BP3 axis inhibits tumor immune surveillance by upregulating N6-methyladenosine modification of PD-L1 mRNA in breast cancer.

Background

Continual expression of PD-L1 in tumor cells is critical for tumor immune escape and host T cell exhaustion, however, knowledge on its clinical benefits through inhibition is limited in breast cancer. N6-methyladenosine (m6A) plays a crucial role in multiple ...
S-EPMC8864846 | biostudies-literature
UnknownMacrophage HM13/SPP Enhances Foamy Macrophage Formation and Atherogenesis.
Aryl Hydrocarbon Receptor-Interacting Protein (AIP) reduces macrophage cholesterol-ester accumulation and may prevent atherogenic foamy macrophage formation. Analyzing AIP-associated regulatory gene networks can aid in identifying key regulatory mechanism(s) underlying foamy macrophage formation. A ...
S-EPMC12079524 | biostudies-literature
UnknownPhotocrosslinking silver nanoparticles-aloe vera-silk fibroin composite hydrogel for treatment of full-thickness cutaneous wounds.
Damage to the skin causes physiological and functional issues. The most effective treatment approach is the use of wound dressings. Silk fibroin (SF) is a promising candidate biomaterial for regulating wound healing; however, its antibacterial properties and biological activity must be further impro...
S-EPMC8419525 | biostudies-literature
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