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TranscriptomicsExpression data from colon fibroblasts treated with Sonic hedgehog homolog (SHH)
Canonical Hedgehog (Hh) signaling regulates the expression of genes that are critical to the patterning and development of a variety of organ systems. In adult, both ligand-dependent and ligand-independent Hh pathway activation are known to promote tumorigenesis. Recent studies have shown that in tu...
ORGANISM(S): Homo sapiens 
2011-05-17 | E-GEOD-29316 | biostudies-arrayexpress
UnknownRandomized phase II trial of Onartuzumab in combination with erlotinib in patients with advanced non-small-cell lung cancer.
Not available
S-EPMC4878106 | biostudies-literature
TranscriptomicsGene expression profiling of HhAntag-treated pancreatic xenografts
Four vehicle-treated and four HhAntag-treated pancreatic xenograft tumors were profiled for gene expression changes using Affymetrix U133 Plus 2.0 and Affymetrix Mouse Genome 430 2.0 arrays. Keywords: comparative gene expression, hedgehog, hh A primary human pancreatic tumor xenograft (1051178-A) w...
ORGANISM(S): Homo sapiens 
2008-09-12 | E-GEOD-11981 | biostudies-arrayexpress
UnknownEvidence for class-specific factors in immunoglobulin isotype switching.
Not available
S-EPMC2193137 | biostudies-literature
UnknownIntranasal Insulin Attenuates the Long-Term Adverse Effects of Neonatal Hyperglycemia on the Hippocampus in Rats.
Not available
S-EPMC9928603 | biostudies-literature
TranscriptomicsDNA Methylation Profiling Defines Clinically Relevant Biological Subsets of Non-small Cell Lung Cancer
PURPOSE: Non-small cell lung cancers (NSCLC) comprise multiple distinct biological groups with different prognoses. For example, patients with epithelial-like (EL) tumors have a better prognosis and exhibit greater sensitivity to inhibitors of the epidermal growth factor receptor (EGFR) pathway than...
ORGANISM(S): Homo sapiens 
2012-03-03 | E-GEOD-36216 | biostudies-arrayexpress
UnknownTreatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449.
Not available
S-EPMC5317279 | biostudies-literature
UnknownEfficacy and safety of vismodegib in advanced basal-cell carcinoma.
Not available
S-EPMC5278761 | biostudies-literature
UnknownA transcriptional MAPK Pathway Activity Score (MPAS) is a clinically relevant biomarker in multiple cancer types.
Not available
S-EPMC5871852 | biostudies-literature
UnknownHigh heregulin expression is associated with activated HER3 and may define an actionable biomarker in patients with squamous cell carcinomas of the head and neck.
Not available
S-EPMC3586092 | biostudies-literature
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