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MetabolomicsAcupuncture Synergized With Bortezomib Improves Survival of Multiple Myeloma Mice via Decreasing Metabolic Ornithine
Multiple myeloma (MM) is a hematological malignancy worldwide in urgent need for novel therapeutic strategies. Since Velcade (bortezomib) was approved for the treatment of relapsed/refractory MM in 2003, we have seen considerable improvement in extending MM patient survival. However, most patients a...
2022-02-21 | MTBLS3487 | MetaboLights
ProteomicsRHOF Activation of AKT/β-Catenin Signaling Pathway Drives Acute Myeloid Leukemia Progression and Chemotherapy Resistance
To further investigate which molecules interact with RHOF in AML，we performed a comparative proteomic analysis of 293T cells overexpressing RHOF and control cells using liquid chromatography‒mass spectrometry.
ORGANISM(S): Homo Sapiens 
2024-05-09 | PXD052126 |
ProteomicsMS Analysis Reveals the Potential Signaling Pathway for RFWD2 Function in multiple myeloma
MS was conducted to assess activation of RFWD2-related signaling pathways.
ORGANISM(S): Homo Sapiens 
2021-03-04 | PXD024507 |
ProteomicsSFXN2 adjusts cell proliferation in multiple myeloma
SFXN2 adjusts cell proliferation in multiple myeloma
ORGANISM(S): Homo Sapiens 
2021-07-28 | PXD027607 |
ProteomicsCD229 promotes multiple myeloma cell proliferation by regulating RAS/ERK pathway
Flag antibody was used for immunoprecipitation, and cd229-OE partial binding protein was searched by protein spectrum in CD229-OE multiple myeloma cell line, and its interaction was analyzed.
ORGANISM(S): Homo Sapiens 
2022-03-09 | PXD032177 |
ProteomicsIntegrative proteomics and metabolomics approach to identify the key roles of icariin-mediated protective effects against cyclophosphamide-induced spermatogenesis dysfunction in mice
The alkylating antineoplastic agent cyclophosphamide (CP) is known to be toxic to the male reproductive system, but there are no effective prevention or treatment options. The flavonoid icariin (ICA), which is used in Chinese medicine, has been shown to have a number of biological functions, includi...
ORGANISM(S): Mus Musculus 
2022-12-05 | PXD038536 |
ProteomicsProteomics analysis of the myocardium form chronic hypobaric hypoxia-induced mice model
C57BL/6J mice were assigned to the hypobaric hypoxia chamber for simulation of high-altitude conditions. iTRAQ proteomics analysis/nanoUHPLC-MS/MS analysis was performed accordingly in the right myocardium of mice that had been allowed to develop hypoxia-induced pulmonary hypertension after hypobari...
ORGANISM(S): Mus Sp. 
2023-02-23 | PXD040342 |
ProteomicsLow-dose metformin targets the lysosome-AMPK pathway through PEN2
Metformin is the most prescribed anti-diabetic medicine, and has also been shown to have other various benefits, such as anti-aging and anti-cancer effects. For clinical doses of metformin, it is known that AMPK plays a major role; however, the direct molecular target of metformin remains unclear. H...
ORGANISM(S): Homo Sapiens Mus Musculus 
2021-12-01 | PXD030090 |
ProteomicsLithocholic acid targets TULP3-Sirtuins to deacetylate v-ATPase and activate AMPK
Lithocholic acid (LCA), accumulated in mammals during calorie restriction (CR), can activate AMP-activated protein kinase (AMPK) and slow down ageing1. However, how LCA is signalled to activate AMPK and elicit the biological effects is unclear. Here, we show that LCA can enhance the activity of sirt...
ORGANISM(S): Homo Sapiens Mus Musculus 
2024-09-16 | PXD056134 |
ProteomicsProteomics and Human Microchips Identify Thrombospondin-1 as a Potential Biomarker for Calciphylaxis Stem Cell Therapy
Calciphylaxis, also known as calcific uremic arteriolopathy (CUA), is a rare disease with high mortality rate. We effectively rescued CUA patients with novel human amnion-derived mesenchymal stem cell (hAMSC) therapy. Due to the heterogeneity of cutaneous lesion, it is imperative to identify non-inv...
ORGANISM(S): Homo Sapiens 
2026-05-14 | PXD078388 |
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