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ProteomicsToward the discovery of biological functions associated with the mechanosensor Mtl1p of Saccharomyces cerevisiae via integrative multi-OMICs analysis.
Functional analysis of the Mtl1 protein in Saccharomyces cerevisiae has revealed that this transmembrane sensor endows yeast cells with resistance to oxidative stress by hydrogen peroxide (H2O2) treatment through a signaling mechanism called the cell wall integrity pathway (CWI). Quantitative mRNA e...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-09-10 | PXD023963 | Pride
General stress response Metabolome Yeast mechanosensors Proteome Yeast cell wall integrity 
TranscriptomicsThe ion channel Trpc6a regulates the cardiomyocyte regenerative response to mechanical stretch
Myocardial damage caused for example by cardiac ischemia leads to ventricular volume overload resulting in increased stretch of the remaining myocardium. In adult mammals, these changes trigger an adaptive cardiomyocyte hypertrophic response which, if the damage is extensive, will ultimately lead to...
ORGANISM(S): Danio rerio 
2023-12-20 | E-MTAB-13603 | biostudies-arrayexpress
UnknownProtein kinase C and calcineurin cooperatively mediate cell survival under compressive mechanical stress.
Not available
S-EPMC5754771 | biostudies-literature
TranscriptomicsSurface topography guides morphology and spatial patterning of induced pluripotent stem cell colonies
The relevance of topographic cues for commitment of induced pluripotent stem cells (iPSCs) is largely unknown. In this study, we demonstrate that groove-ridge structures with a periodicity in the submicrometer range induce elongation of iPSC colonies, guide the orientation of apical actin fibers, an...
ORGANISM(S): Homo sapiens 
2018-10-31 | E-MTAB-7327 | biostudies-arrayexpress
TranscriptomicsMechanical loading and gene expression - Microarray study
Skeletal integrity in humans and animals is maintained by daily mechanical loading. It has been widely accepted that osteocytes function as mechanosensors. Many biochemical signaling molecules are involved in the response of osteocytes to mechanical stimulation. The aim of this study was to identify...
ORGANISM(S): Rattus norvegicus 
2013-11-21 | E-GEOD-50707 | biostudies-arrayexpress
TranscriptomicsRNAseq of human aortic endothelial cells (TeloHAECs) under unidirectional flow (UF) and disturbed flow (DF).
Our goal was to identify differentially expressed genes in control endothelial cells subjected to varying mechanical forces (flow).
ORGANISM(S): Homo sapiens 
2026-04-10 | E-MTAB-16095 | biostudies-arrayexpress
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