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ProteomicsPartner of Yeast Telomerase TLC1 RNA (TLC1)
Identification of yeast telomerase protein composition.
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2016-04-26 | PXD003273 | Pride
Yeast telomerase 
TranscriptomicsTranscription profiling of Arabidopsis 3 week old plant leaves Overexpressing of TELOMERASE ACTIVATOR 1 (TAC1) vs controls
The goal of this investigation was to identify putative targets of the TELOMERASE ACTIVATOR 1 transcription factor. Experiment Overall Design: Total RNA was isolated from leaves of 3 week old plants. We used three biological replicates of wild type (Columbia) and the tac1-1D activation tagged line ...
ORGANISM(S): Arabidopsis thaliana 
2008-06-14 | E-GEOD-5896 | biostudies-arrayexpress
ProteomicsProteomic analysis defines the interactome of telomerase in the protozoan parasite, Trypanosoma brucei
Telomeres are the nucleoprotein structures found at the ends of eukaryotic chromosomes. Conventional DNA polymerases are unable to fully replicate the telomeric end of the chromosome, which leads to a progressive loss of DNA after every cell division. This problem is solved by the ribonucleoprotein ...
ORGANISM(S): Trypanosoma brucei 
2023-03-08 | PXD038235 | Pride
Co-immunoprecipitation Telomerase Interaction partners Trypanosoma brucei Telomerase rna Lc-ms/ms 
TranscriptomicsTelomerase subunit TERT regulates MYC stability independent of its role on telomeres (array)
Constitutively active MYC and reactivated telomerase often co-exist in cancers. While the reactivation of telomerase is thought to be essential for replicative immortality, MYC, in conjunction with co-factors, confers several growth advantages to cancer cells. However, it is unclear which co-factors...
ORGANISM(S): Homo sapiens 
2015-04-23 | E-GEOD-60175 | biostudies-arrayexpress
ProteomicsMudPIT analysis of S. pombe proteins interacting with Pof8
To identify proteins interacting with Pof8, cell-free extracts of strains FP1547 harboring 3xFLAG epitope-tagged Pof8 and untagged control (FP1546) were diluted to 5 mg/ml in 8 ml of lysis buffer (50 mM Tris-HCl pH 7.5, 150 mM sodium chloride, 0.1% (v/v) NP40 and 10% (v/v) glycerol) plus complete ED...
ORGANISM(S): Schizosaccharomyces Pombe (ncbitaxon:4896) 
2021-05-24 | MSV000087493 | MassIVE
TranscriptomicsTelomerase is a prognostic marker of poor outcome and a therapeutic target in neuroblastoma
The aim of this study is to determine the clinical relevance of telomerase activation versus ALT as biomarkers in pre-treatment neuroblastoma, and to assess the potential value of telomerase as a therapeutic target. Therefore, the genomic status of TERT and MYCN was assessed in 457 pretreatment neur...
ORGANISM(S): Homo sapiens 
2019-09-16 | E-MTAB-8248 | biostudies-arrayexpress
GenomicsPof8 is a La-related protein and a constitutive component of telomerase in fission yeast
Pof8 is a La-related protein and a constitutive component of telomerase in fission yeast
PRJNA413463 | ENA
TranscriptomicsEvaluating the effects of cardiac telomerase re-activation after myocardial infarction in adult mice
Coronary heart disease is a main cause of death in the developed world and treatment success remains modest with high mortality rates within one year after myocardial infarction (MI). Thus, new therapeutic targets and effective treatments are necessary. Short telomeres are risk factors for age-assoc...
ORGANISM(S): Mus musculus 
2014-12-15 | E-GEOD-62973 | biostudies-arrayexpress
TranscriptomicsDeterminants of divergent adaptation and Dobzhansky-Muller interaction in experimental yeast populations
Divergent adaptation can be associated with reproductive isolation in the process of speciation. We recently demonstrated the link between divergent adaptation and the onset of reproductive isolation in experimental populations of the yeast Saccharomyces cerevisiae evolved from a single progenitor ...
ORGANISM(S): Saccharomyces cerevisiae 
2010-07-15 | E-GEOD-20943 | biostudies-arrayexpress
UnknownTelomerase activation after recruitment in fission yeast.
Not available
S-EPMC4159562 | biostudies-literature
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