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TranscriptomicsTranscription profiling of Arabidopsis 3 week old plant leaves Overexpressing of TELOMERASE ACTIVATOR 1 (TAC1) vs controls
The goal of this investigation was to identify putative targets of the TELOMERASE ACTIVATOR 1 transcription factor. Experiment Overall Design: Total RNA was isolated from leaves of 3 week old plants. We used three biological replicates of wild type (Columbia) and the tac1-1D activation tagged line ...
ORGANISM(S): Arabidopsis thaliana 
2008-06-14 | E-GEOD-5896 | biostudies-arrayexpress
TranscriptomicsTelomerase subunit TERT regulates MYC stability independent of its role on telomeres (array)
Constitutively active MYC and reactivated telomerase often co-exist in cancers. While the reactivation of telomerase is thought to be essential for replicative immortality, MYC, in conjunction with co-factors, confers several growth advantages to cancer cells. However, it is unclear which co-factors...
ORGANISM(S): Homo sapiens 
2015-04-23 | E-GEOD-60175 | biostudies-arrayexpress
GenomicsTelomerase subunit TERT regulates MYC stability independent of its role on telomeres (ChIP-Seq)
Constitutively active MYC and reactivated telomerase often co-exist in cancers. While the reactivation of telomerase is thought to be essential for replicative immortality, MYC, in conjunction with co-factors, confers several growth advantages to cancer cells. However, it is unclear which co-factors...
ORGANISM(S): Mus musculus 
2015-04-23 | E-GEOD-60223 | biostudies-arrayexpress
ProteomicsProteomic analysis defines the interactome of telomerase in the protozoan parasite, Trypanosoma brucei
Telomeres are the nucleoprotein structures found at the ends of eukaryotic chromosomes. Conventional DNA polymerases are unable to fully replicate the telomeric end of the chromosome, which leads to a progressive loss of DNA after every cell division. This problem is solved by the ribonucleoprotein ...
ORGANISM(S): Trypanosoma brucei 
2023-03-08 | PXD038235 | Pride
Co-immunoprecipitation Telomerase Interaction partners Trypanosoma brucei Telomerase rna Lc-ms/ms 
ProteomicsDisruption of ZC3H15 Compromises Telomere Length Maintenance by Sequestering Telomerase within Cajal bodies
Telomere homeostasis, crucial for various biological processes, relies on telomerase activity. We identified ZC3H15 as a novel telomerase-interacting protein. Its deletion unexpectedly increased telomerase activity but led to shortened telomeres and cellular senescence. ZC3H15 interacts with telomer...
ORGANISM(S): Homo Sapiens 
PXD052036 |
TranscriptomicsTelomerase is a prognostic marker of poor outcome and a therapeutic target in neuroblastoma
The aim of this study is to determine the clinical relevance of telomerase activation versus ALT as biomarkers in pre-treatment neuroblastoma, and to assess the potential value of telomerase as a therapeutic target. Therefore, the genomic status of TERT and MYCN was assessed in 457 pretreatment neur...
ORGANISM(S): Homo sapiens 
2019-09-16 | E-MTAB-8248 | biostudies-arrayexpress
GenomicsTelomerase activation by genomic rearrangements in high-risk neuroblastoma
Neuroblastoma is a malignant pediatric tumor of the sympathetic nervous system1. Roughly half of these tumors regress spontaneously or are cured by limited therapy. By contrast, high-risk neuroblastomas have an unfavorable clinical course despite intensive multimodal treatment, and their molecular b...
EGAS00001001308 | EGA
GenomicsGenome-wide TNFM-NM-1-induced p65 binding before and after telomerase inhibition in HeLa cells
Chromatin immunoprecipitation sequencing (ChIP-seq) was performed to analyze the effect of telomerase inhibition on TNFM-NM-1-induced genome-wide p65 binding in HeLa cells. By obtaining over 40 million uniquely mappable reads per sample from ChIP-seq, maps for TNFM-NM-1-induced p65 binding in absenc...
ORGANISM(S): Homo sapiens 
2012-11-26 | E-GEOD-41100 | biostudies-arrayexpress
TranscriptomicsEvaluating the effects of cardiac telomerase re-activation after myocardial infarction in adult mice
Coronary heart disease is a main cause of death in the developed world and treatment success remains modest with high mortality rates within one year after myocardial infarction (MI). Thus, new therapeutic targets and effective treatments are necessary. Short telomeres are risk factors for age-assoc...
ORGANISM(S): Mus musculus 
2014-12-15 | E-GEOD-62973 | biostudies-arrayexpress
ProteomicsPeroxiredoxin 1 protects telomeres from oxidative damage preserving chromosome ends for extension by telomerase
With the increase of atmospheric oxygen 2.3 billion years ago, mechanisms evolved to mitigate the toxic effects of oxygen radicals. Telomeres appear particularly susceptible to oxidative damage, which leads to cellular and organismal aging, cancer, cardiac failure and other diseases. Specific mechan...
ORGANISM(S): Homo sapiens (Human) 
2016-12-07 | PXD002626 | Pride
Peroxiredoxin 1  telomeres  oxidative damage  telomerase 
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