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ProteomicsMixed Alkyl/Aryl Phosphonates Identify Metabolic Serine Hydrolases as Antimalarial Targets
Malaria, caused by Plasmodium falciparum, remains a significant health burden. The barrier for developing anti-malarial drugs is the ability of the parasite to rapidly generate resistance. We previously demonstrated that Salinipostin A (SalA), a natural product, potently kills parasites by inhibitin...
ORGANISM(S): Homo sapiens (Human) Plasmodium falciparum (isolate 3D7) 
2024-07-15 | PXD051499 | Pride
Plasmodium Lipid metabolism Serine hydrolases Activity-based probes 
UnknownHuR Contributes to TRAIL Resistance by Restricting Death Receptor 4 Expression in Pancreatic Cancer Cells.
Not available
S-EPMC5312260 | biostudies-literature
TranscriptomicsTranscriptome-wide Regulation of Splicing and mRNA Localization by Muscleblind Proteins
The Muscleblind-like (Mbnl) family of RNA-binding proteins plays important roles in muscle and eye development and in Myotonic Dystrophy (DM), where expanded CUG or CCUG repeats functionally deplete Mbnl proteins. We identified transcriptome-wide functional and biophysical targets of Mbnl proteins i...
ORGANISM(S): Drosophila melanogaster 
2012-08-17 | E-GEOD-39911 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array time series of human MCF7 breast cancer cells treated with estradiol
Using a chromatin immunoprecipitation-paired end diTag cloning and sequencing strategy, we mapped estrogen receptor alpha (ERalpha) binding sites in MCF-7 breast cancer cells. We identified 1,234 high confidence binding clusters of which 94% are projected to be bona fide ERalpha binding regions. Onl...
ORGANISM(S): Homo sapiens 
2009-01-09 | E-GEOD-11352 | biostudies-arrayexpress
UnknownEarly trajectories of virological and immunological biomarkers and clinical outcomes in patients admitted to hospital for COVID-19: an international, prospective cohort study.
Not available
S-EPMC11181148 | biostudies-literature
UnknownTranscriptome changes affecting Hedgehog and cytokine signalling in the umbilical cord: implications for disease risk.
Not available
S-EPMC3393728 | biostudies-literature
UnknownProspective associations of appetitive traits at 3 and 12 months of age with body mass index and weight gain in the first 2 years of life.
Not available
S-EPMC4603814 | biostudies-literature
UnknownHIF3A association with adiposity: the story begins before birth.
Not available
S-EPMC4863876 | biostudies-literature
UnknownDevelopmental pathways to adiposity begin before birth and are influenced by genotype, prenatal environment and epigenome.
Not available
S-EPMC5340003 | biostudies-literature
UnknownPertuzumab, trastuzumab, and docetaxel in HER2-positive metastatic breast cancer.
Not available
S-EPMC5584549 | biostudies-literature
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