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GenomicsGenome-wide analysis of Yki and Sd localization in imaginal disks of Drosophila eye by ChIP Seq
Throughout Metazoa, developmental processes are controlled by a surprisingly limited number of conserved signaling pathways. Precisely how these signaling cassettes were assembled in early animal evolution remains poorly understood, as do the molecular transitions that potentiated the acquisition o...
ORGANISM(S): Drosophila melanogaster 
2014-03-01 | E-GEOD-54601 | biostudies-arrayexpress
ProteomicsYorkie and Bonus protein interactome-Hippo pathway and Bonus control developmental cell fate decisions in the Drosophila eye
To identify novel regulators of the Hippo pathway, we performed affinity purification-mass spectrometry (AP-MS) using Drosophila embryos overexpressing Yki-EGFP with a ubiquitous driver da-GAL4, as well as cultured S2 cells expressing Yki-SBP. We identified the core Hippo pathway components, multipl...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2023-01-17 | PXD027934 | Pride
Embryo Drosophila Yki S2 cell Bon Lc-ms/ms 
TranscriptomicsGenome-wide binding of Sd and Yki in imaginal discs
The transcription cofactor Yki drives growth and proliferation in part by controlling mitochondrial network formation. To determine if Yki and Sd are directly bound to DNA corresponding to mitochondrial genes, we used chromatin immunoprecipitation and whole genome tiling arrays (ChIP-chip) to identi...
ORGANISM(S): Drosophila melanogaster 
2012-10-03 | E-GEOD-26678 | biostudies-arrayexpress
GenomicsTranscriptomic analysis of flies with Yki gut tumors
Transcriptomic analysis of flies with Yki gut tumors
PRJNA954832 | ENA
ProteomicsProteome of Yki-driven intestinal stem cell tumors in Drosophila midgut
The experiment was undertaken to characterize Yki-driven intestinal stem cell tumor proteome from Drosophila adult midguts, and to identify changes in the ISC tumor proteome in flies fed on TONDU peptide, using LC MS/MS approach. esgts>UAS-yki3SA flies on day 1, day 7 of tumor induction; TONDU-pepti...
ORGANISM(S): Drosophila Melanogaster (ncbitaxon:7227) 
2020-01-25 | MSV000084841 | MassIVE
GenomicsPromoter proximal pausing limits Yki-induced tumorous growth in Drosophila
Promoter proximal pausing limits Yki-induced tumorous growth in Drosophila
PRJNA637769 | ENA
GenomicsRNA-sequencing analysis of Drosophila yki tumor tissue
RNA-sequencing analysis of Drosophila yki tumor tissue
PRJNA646198 | ENA
TranscriptomicsYki-induced intestinal stem cells (ISCs) overproliferation remotely affects muscular gene expression in Drosophila
Purpose: localized aberrant cell proliferation induced by activation of Yki in ISCs impairs muscle functions. To gain insight into the cross talk between intestine and muscle, we performed a transcriptomic analysis of thoracic muscles in ISC overproliferation flies. Methods: To extract total RNAs fo...
ORGANISM(S): Drosophila melanogaster 
2015-02-01 | E-GEOD-65325 | biostudies-arrayexpress
TranscriptomicsTranscriptomic analysis of flies with Yki gut tumors
Purpose: Flies with Yki gut tumors is a widely used Drosophila model of cancer cachexia. Since cancer cachexia is a multi-organ syndrome, its investigation requires understanding how tumors induce metabolic dysfunction in peripheral organs. To address this, we performed a body-wide single-cell trans...
ORGANISM(S): Drosophila melanogaster 
2025-02-21 | GSE229526 | GEO
GenomicsGenome-wide binding of Sd and Yki in imaginal discs
The transcription cofactor Yki drives growth and proliferation in part by controlling mitochondrial network formation. To determine if Yki and Sd are directly bound to DNA corresponding to mitochondrial genes, we used chromatin immunoprecipitation and whole genome tiling arrays (ChIP-chip) to identi...
ORGANISM(S): Drosophila melanogaster 
2012-10-03 | GSE26678 | GEO
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