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We performed ChIP-seq to chart genome-wide maps of H3K27me3 in brown preadipocytes and mature brown adipocytes. We observed a subset of brown fat-specific genes, but not common fat genes or white fat-specific genes, possess the H3K27me3 mark in preadipocytes, and this mark is erased in mature adipoc...
ORGANISM(S): Mus musculus 

The gut microbiome has emerged as a potential factor in cancer pathogenesis, but its role in non-functioning pituitary neuroendocrine tumors (NF-PitNETs) remains unclear. This study aimed to elucidate gut microbiome and metabolomic alterations in NF-PitNETs by comparing microbial diversity, patho...

2025-06-16 | MTBLS12328 | MetaboLights
This study aimed to identify miRNAs enriched in exosomes that promote osteolytic bone metastasis. We performed miRNA-seq directly on exosomes purified from the culture supernatants of either non-metastatic (NC-LLC) or bone-metastatic (BM-LLC) Lewis lung carcinoma cells. The goal was to profile the m...
ORGANISM(S): Mus musculus 
Cancer secretome is a reservoir for aberrant glycosylation. How therapies alter this post translational cancer hallmark and the consequences thereof remain elusive. Here we show that an elevated secretome fucosylation is a pan-cancer signature of both response and resistance to multiple targeted the...
ORGANISM(S): Homo sapiens (Human) 
2023-04-05 | PXD022240 | Pride
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