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MetabolomicsUntargeted LC-MS metabolomics for the analysis of micro-scaled extracellular metabolites from hepatocytes
Metabolome analysis in micro physiological models is a challenge due to the low volume of cell culture medium (CCM). Here, we report a LC-MS-based untargeted metabolomics protocol for the detection of hepatocyte extracellular metabolites from micro-scale samples of CCM. Using a single LC-MS method w...
2021-01-04 | MTBLS1794 | MetaboLights
MetabolomicsSpatiotemporal determination of metabolite activities in the corneal epithelium on a chip
The corneal epithelial barrier maintains the metabolic activities of the ocular surface by regulating membrane transporters and metabolic enzymes responsible for the homeostasis of the eye as well as the pharmacokinetic behavior of drugs. Despite its importance, no established biomimetic in vitro me...
2021-07-13 | MTBLS2274 | MetaboLights
UnknownAn Overview of the Recent Development of Anticancer Agents Targeting the HIF-1 Transcription Factor.
Not available
S-EPMC8200185 | biostudies-literature
GenomicsRNA methylation-dependent RNA processing controls the speed of the circadian clock
To investigate the major components of the response to the methylation inhibitor 3-deazadenosine U2OS cells were plated in 20 cm dishes and grown until confluence. Cells were then treated with 100 microM deazaadenosine or vehicle (PBS) for 24 hours. Three replicate dishes for each treatment were ana...
ORGANISM(S): Homo sapiens 
2013-11-07 | E-GEOD-48037 | biostudies-arrayexpress
UnknownTrends in effectiveness of inactivated influenza vaccine in children by age groups in seven seasons immediately before the COVID-19 era.
Not available
S-EPMC8995322 | biostudies-literature
TranscriptomicsLoss of Tifab, a del(5q) MDS gene, alters hematopoiesis through derepression of Toll-like receptor/TRAF6 signaling
TRAF-interacting protein with forkhead-associated domain B (TIFAB) is a haploinsufficient gene in del(5q) Myelodysplastic syndrome (MDS). Hematopoietic-specific deletion of Tifab results in progressive bone marrow (BM) and blood defects, including skewed hematopoietic stem/progenitor cells (HSPC) pr...
ORGANISM(S): Mus musculus 
2015-09-12 | E-GEOD-72936 | biostudies-arrayexpress
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