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TranscriptomicsGene expression profiling in murine Smad-deficient CD4+ T cells stimulated with TGF-b
TGF-b is an important pleiotropic cytokine with potent immunoregulatory properties. Although many previous reports have been proposed for the immunoregulatory functions of TGF-b on T cells, such as the suppression of cell proliferation, cytokine production and cytokine signaling, as well as the indu...
ORGANISM(S): Mus musculus 
2010-07-29 | E-GEOD-19601 | biostudies-arrayexpress
TranscriptomicsInvolvement of Nr4a in a Treg-specific transcriptional program and suppression ofM-cM-^@M-^@Th2/Tfh response
Regulatory T (Treg) cells, as central mediators of immune suppression, play crucial roles in many aspects of immune system physiology and pathophysiology. Treg cells are characterized by a distinct pattern of gene expression, including upregulation of immune-suppressive genes and silencing of inflam...
ORGANISM(S): Mus musculus 
2013-12-23 | E-GEOD-53574 | biostudies-arrayexpress
GenomicsGenome-wide ChIP-seq analysis of Nr4a1 binding sites in regulatory T (Treg) cells
We have revealed that Nr4a family nuclear orphan receptors broadly regulate a transcriptional program in Treg cells. In this study, to give an insight into Nr4a-mediated regulation of the transcriptional program in Treg cells, we performed ChIP-seq experiment using anti-Nr4a1 antibodies and a chroma...
ORGANISM(S): Mus musculus 
2015-06-30 | E-GEOD-70417 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse bone marrow-derived dendritic cells stimilated with LPS in the presence or absence of cAMP
genes regualted by LPS or LPS+cAMP stimulation in BMDCs; We used microarrays to identify genes that up-regulated by LPS+cAMP compared with just LPS. Experiment Overall Design: BMDCs were stimilated with LPS (10 ng/ml) in the presence or absence of cAMP (100 microM) for 3h. Specifically up-regualted ...
ORGANISM(S): Mus musculus 
2009-07-05 | E-GEOD-16761 | biostudies-arrayexpress
TranscriptomicsProfiling gene expression of ETV2-induced vascular endothelial cells (ETVECs)
ETV2 induces expression of endothelial-specific genes in primary human adult skin fibroblasts (HAFs) Human unbillical vein endothelial cells (HUVECs) are used as a control 32 days after ETV2 induction into HAFs, cells are recognized as ETVECs. ETVECs were created from three independent skin donor. E...
ORGANISM(S): Homo sapiens 
2013-07-19 | E-GEOD-48980 | biostudies-arrayexpress
TranscriptomicsComparison of mRNA expression pattern between wild-type regulatory T (Treg) cells and Nr4a-deficient Treg cells
Regulatory T (Treg) cells, as central mediators of immune suppression, play crucial roles in many aspects of immune system physiology and pathophysiology. Treg cells are characterized by a distinct pattern of gene expression, including upregulation of immune-suppressive genes and silencing of inflam...
ORGANISM(S): Mus musculus 
2015-06-27 | E-GEOD-70306 | biostudies-arrayexpress
GenomicsExpression profile of cultured CD4 T cells
Expression profile of cultured CD4 T cells
PRJNA432918 | ENA
TranscriptomicsA gp130-induced Src/Yes-YAP Cascade Links Inflammation to Regeneration in the Mammalian Intestine
gp130Act cDNA was PCR-amplified and inserted into a plasmid containing the 12.4-kb Villin promoter. The 15.7-kb expression cassette was excised by PmeI digestion, purified, and injected into fertilized C57BL/6 oocytes to obtain founder mice, two of which transmitted the gp130Act transgene. Small int...
ORGANISM(S): Mus musculus 
2015-02-21 | E-MTAB-2400 | biostudies-arrayexpress
TranscriptomicsCLP1 links tRNA metabolism to progressive motor-neuron loss
CLP1 was the first mammalian RNA kinase to be identified. However, determining its in vivo function has been elusive. Here we generated kinase-dead Clp1 (Clp1K/K) mice that show a progressive loss of spinal motor neurons associated with axonal degeneration in the peripheral nerves and denervation of...
ORGANISM(S): Mus musculus 
2013-03-12 | E-GEOD-35924 | biostudies-arrayexpress
ModelsYamada2003_JAK_STAT_pathway
NCBS Curation Comments This model shows the control mechanism of Jak-Stat pathway, here SOCS1 (Suppressor of cytokine signaling-I) was identified as the negative regulator of Jak and STAT signal transduction pathway. Note: There are a few ambiguities in the paper like initial concentration...
2024-09-02 | BIOMD0000000093 | BioModels
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