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TranscriptomicsMicroarray analysis of colon tissue of DSS colitis STAP-2 KO mice
To identify STAP-2 regulating genes modulated intestine inflammation, we conducted microarray analyses using colon tissue from pooled WT (n=3) or STAP-2-/- mice (n=3) treated with DSS for 3 days. Bioinformatic analyses revealed that STAP-2 deletion mediates insufficient immune and inflammatory react...
ORGANISM(S): Mus musculus 
2014-04-17 | E-GEOD-48543 | biostudies-arrayexpress
UnknownNR4A ablation improves mitochondrial fitness for long persistence in human CAR-T cells against solid tumors.
Not available
S-EPMC11331892 | biostudies-literature
ProteomicsPlasma proteomics of BACE1, 2, and double KO mice
The beta-secretase BACE1 is a central drug target for Alzheimer’s disease. Clinically tested, BACE1-directed inhibitors also block the homologous protease BACE2. Yet, little is known about physiological BACE2 substrates and functions in vivo. Here, we performed glycoprotein enrichment and subsequent...
ORGANISM(S): Mus musculus (Mouse) 
2024-06-27 | PXD041577 | Pride
Bace2 Glycocapture Beta secretase Plasma 
TranscriptomicsGene expression profiling in murine Smad-deficient CD4+ T cells stimulated with TGF-b
TGF-b is an important pleiotropic cytokine with potent immunoregulatory properties. Although many previous reports have been proposed for the immunoregulatory functions of TGF-b on T cells, such as the suppression of cell proliferation, cytokine production and cytokine signaling, as well as the indu...
ORGANISM(S): Mus musculus 
2010-07-29 | E-GEOD-19601 | biostudies-arrayexpress
ProteomicsPlasma proteomics of BACE2 KO mice
The beta-secretase BACE1 is a central drug target for Alzheimer’s disease. Clinically tested, BACE1-directed inhibitors also block the homologous protease BACE2. Yet, little is known about physiological BACE2 substrates and functions in vivo. Here, we performed discovery proteomics to identify subst...
ORGANISM(S): Mus musculus (Mouse) 
2024-06-27 | PXD041579 | Pride
Bace2 Beta secretase Plasma Mouse 
UnknownIdentification and characterization of Arabidopsis AtNUDX9 as a GDP-d-mannose pyrophosphohydrolase: its involvement in root growth inhibition in response to ammonium.
Not available
S-EPMC4566977 | biostudies-literature
TranscriptomicsCLP1 links tRNA metabolism to progressive motor-neuron loss
CLP1 was the first mammalian RNA kinase to be identified. However, determining its in vivo function has been elusive. Here we generated kinase-dead Clp1 (Clp1K/K) mice that show a progressive loss of spinal motor neurons associated with axonal degeneration in the peripheral nerves and denervation of...
ORGANISM(S): Mus musculus 
2013-03-12 | E-GEOD-35924 | biostudies-arrayexpress
UnknownGeneration of c-Fos knockout rats, and observation of their phenotype.
Not available
S-EPMC9978135 | biostudies-literature
UnknownElucidating the Proximal Tubule HNF4A Gene Regulatory Network in Human Kidney Organoids.
Not available
S-EPMC10561821 | biostudies-literature
UnknownSpred2 Regulates High Fat Diet-Induced Adipose Tissue Inflammation, and Metabolic Abnormalities in Mice.
Not available
S-EPMC6349710 | biostudies-literature
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