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ProteomicsPlasma proteomics of BACE2 KO mice
The beta-secretase BACE1 is a central drug target for Alzheimer’s disease. Clinically tested, BACE1-directed inhibitors also block the homologous protease BACE2. Yet, little is known about physiological BACE2 substrates and functions in vivo. Here, we performed discovery proteomics to identify subst...
ORGANISM(S): Mus musculus (Mouse) 
2024-06-27 | PXD041579 | Pride
Bace2 Beta secretase Plasma Mouse 
GenomicsTranscriptome analysis after BACE2 silencing in ocular melanoma cella
Transcriptome analysis after BACE2 silencing in ocular melanoma cella
PRJNA650185 | ENA
ProteomicsBACE2 and lipid metabolism (global proteomic analysis)
global proteomic analysis of melanoma cell lines expressing different bace2 levels
ORGANISM(S): Homo sapiens (Human) 
2026-02-09 | PXD058702 | Pride
Bace2 lipid metabolism cancer 
TranscriptomicsTranscriptome analysis after BACE2 silencing in ocular melanoma cella
In order to study the mechanism of BACE2 and the development of melanoma, we established a model of low expression of BACE2 in melanoma. The results showed that the expression of tmem38b was decreased after BACE2 knockdown, and the intracellular calcium concentration was decreased. In order to revea...
ORGANISM(S): Homo sapiens 
2020-12-31 | GSE155530 | GEO
UnknownRCAN1 Inhibits BACE2 Turnover by Attenuating Proteasome-Mediated BACE2 Degradation.
Not available
S-EPMC7293731 | biostudies-literature
GenomicsBACE2 inhibition impairs oncogenic programs and extracellular vesicle-mediated tumor proliferation in Ewing sarcoma
BACE2 inhibition impairs oncogenic programs and extracellular vesicle-mediated tumor proliferation in Ewing sarcoma
PRJNA1079801 | ENA
ProteomicsProteomics of BACE2 inhibition on patient-derived EWS cells
Ewing sarcoma (EWS), a highly aggressive cancer with limited treatment options and low survival rates. Transcriptomics revealed β-Secretase 2 (BACE2) presence while BACE2 inhibition attenuated EWS cell growth, abolished tumor-initiating capacity, and altered cell cycle/metastatic signatures. To furt...
ORGANISM(S): Homo sapiens (Human) 
2026-09-03 | PXD049183 | Pride
Proteomics Lc-ms Bace2 Ewing sarcoma Inhibition Cell line 
TranscriptomicsBACE2 inhibition impairs oncogenic programs and extracellular vesicle-mediated tumor proliferation in Ewing sarcoma
Ewing sarcoma (EWS) is an aggressive pediatric malignancy with poor outcomes in relapsed or metastatic disease and limited targeted therapeutic options. To identify disease-relevant vulnerabilities, we employed a propagatable patient-derived xenograft (pPDX) platform in which serial in vivo passagin...
ORGANISM(S): Homo sapiens 
2026-09-08 | GSE256506 | GEO
TranscriptomicsGlobal gene expression profile of hIAPP-Tg mice, BACE2-KO mice and hIAPP-TgxBACE2-KO mice
12 weeks old wild type, hIAPP transgenic, BACE2 deficient and both overexpressing hIAPP and lacking BACE2 mice were taken for the study. Pancreatic islets were isolated at sacrifice. RNA was extracted and hybridized on Affymetrix microarrays. We used microarrays to determine gene expression changes ...
ORGANISM(S): Mus musculus 
2017-05-03 | GSE94672 | GEO
UnknownBACE2: A Promising Neuroprotective Candidate for Alzheimer's Disease.
Not available
S-EPMC10473127 | biostudies-literature
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