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ProteomicsSequential Glycosylations at the Multibasic Cleavage Site of SARS-CoV-2 Spike Protein Regulate Viral Activation, Assembly, and Infection
The multibasic furin cleavage site at the S1/S2 boundary of the spike protein (S protein) is a hallmark of SARS-CoV-2 and plays an crucial role in viral infection. O-glycosylation near the furin site catalyzed by host cell glycosyltransferases can theoretically hinder spike protein processing and im...
ORGANISM(S): Homo sapiens (Human) 
2024-03-21 | PXD049110 | Pride
Sars-cov-2 O-glycosylation Galnac-t7 Viral assembly 
ProteomicsProximity Labeling and Genetic Screening Reveals the Role of DSG2/Siglec-9 Axis in Suppressing Macrophage Phagocytosis
In current study, we have established a combined strategy using proximity labeling and genetic screening to identify the cellular ligands of Siglec-9. Our use of proximity labeling using APEX2 fusion proteins followed by quantitative proteomics allowed us to efficiently label and enrich cell surface...
ORGANISM(S): Homo sapiens (Human) 
2024-12-23 | PXD051557 | Pride
Siglec-9 Apex2 Dsg2 Proximity label 
UnknownDimensional Reduction Enhances Photodynamic Therapy of Metal-Organic Nanophotosensitizers.
Not available
S-EPMC9396732 | biostudies-literature
UnknownMyeloid loss of Beclin 1 promotes PD-L1hi precursor B cell lymphoma development.
Not available
S-EPMC6877338 | biostudies-literature
UnknownBrain tumor feature extraction and edge enhancement algorithm based on U-Net network.
Not available
S-EPMC10687284 | biostudies-literature
UnknownSARS-CoV-2 Mpro inhibitors with antiviral activity in a transgenic mouse model.
Not available
S-EPMC8099175 | biostudies-literature
UnknownAI-Driver: an ensemble method for identifying driver mutations in personal cancer genomes.
Not available
S-EPMC7671397 | biostudies-literature
UnknownEffects of Peanut Rust Disease (Puccinia arachidis Speg.) on Agricultural Production: Current Control Strategies and Progress in Breeding for Resistance.
Not available
S-EPMC10815183 | biostudies-literature
UnknownEpidemiological characteristics of centenarian deaths in China during 2013-2020: A trend and subnational analysis.
Not available
S-EPMC11230835 | biostudies-literature
UnknownSingle-cell transcriptome analysis reveals cellular heterogeneity in the ascending aortas of normal and high-fat diet-fed mice.
Not available
S-EPMC8492660 | biostudies-literature
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