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ProteomicsIdentification of a catecholamine- and drug-target, the α2A-adrenoceptor, in human testis and human testicular perit-ubular cells
Abstract: Clonidine has been used in clinical medicine, e.g. to treat high blood pressure, and its use has been linked to impairments of male fertility, but the underlying reasons are not known. Clonidine is an agonist at the α2A-adrenoceptor (ADRA2A) which is expressed by cells of the testis, hence...
ORGANISM(S): Homo sapiens (Human) 
2024-10-17 | PXD052220 | Pride
Human male fertility  human testis Testis Inflammation Contraction Peritubular cell Cytokines Alpha-adrenoreceptor Clonidine Sperm transport 
ProteomicsDexamethasone is a regulator of human testicular peritubular cells / Proteome 24 h
The functions of human testicular peritubular cells (HTPCs), which form a small compartment located between the seminiferous epithelium and the interstitials areas of the testis, go beyond intratesticular sperm transport and include immunological roles. The expression of the glucocorticoid receptor ...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD033514 | Pride
Human male fertility  human testis  dexamethasone  cytokines  inflammation  proteomics 
ProteomicsDexamethasone is a regulator of human testicular peritubular cells / Proteome 72 h
The functions of human testicular peritubular cells (HTPCs), which form a small compartment located between the seminiferous epithelium and the interstitials areas of the testis, go beyond intratesticular sperm transport and include immunological roles. The expression of the glucocorticoid receptor ...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD033534 | Pride
Human male fertility  human testis  dexamethasone  cytokines  inflammation  proteomics 
ProteomicsDexamethasone is a regulator of human testicular peritubular cells / Secretome Data
The functions of human testicular peritubular cells (HTPCs), which form a small compartment located between the seminiferous epithelium and the interstitials areas of the testis, go beyond intratesticular sperm transport and include immunological roles. The expression of the glucocorticoid receptor ...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD033504 | Pride
Human male fertility  human testis  dexamethasone  cytokines  inflammation  proteomics 
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