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TranscriptomicsDo different neurons age differently? Direct genome-wide analysis of aging in single identified cholinergic neurons
The complexity of events associated with age-related memory loss (ARML) cannot be overestimated. The problem is further complicated by the enormous diversity of neurons in the CNS and even synapses of one neuron within a neural circuit. Large-scale single-neuron analysis is not only challenging but ...
ORGANISM(S): Aplysia californica 
2010-05-20 | E-GEOD-18783 | biostudies-arrayexpress
UnknownNear-Infrared Reflectance Imaging in Retinal Diseases Affecting Young Patients.
Not available
S-EPMC8349282 | biostudies-literature
ProteomicsIgM hyposialylation drives podocyte injury in pediatric and young adult patients with podocytopathies
Altered immunoglobulin glycosylation has been implicated in antibody-mediated podocytopathies, yet the functional impact of IgM sialylation remains unclear. Previous evidence suggested that circulating cationic or hyposialylated IgM may contribute to podocyte injury in idiopathic nephrotic syndrome ...
ORGANISM(S): Homo sapiens (Human) 
2026-06-29 | PXD070406 | Pride
Immunoglobulin m glycosylation Hyposialylation Sialidase Podocyte injury Podocytopathies 
UnknownHistory of Migraine and Volume of Brain Infarcts: The Italian Project on Stroke at Young Age (IPSYS).
Not available
S-EPMC6780016 | biostudies-literature
Unknown"Poker" association of weekly alternating 5-fluorouracil, irinotecan, bevacizumab and oxaliplatin (FIr-B/FOx) in first line treatment of metastatic colorectal cancer: a phase II study.
Not available
S-EPMC2972284 | biostudies-literature
UnknownRadiation therapy for older patients with brain tumors.
Not available
S-EPMC5477302 | biostudies-literature
ProteomicsProteomic elucidation of fructose-diet associated molecular alterations in hypothalamus of adolescent rats
The crucial role of nutrition for cerebral health and the impact of dietary habits on brain structure and function have been long far recognized. To date a major health concern is associated with the increased consumption of fructose as added sugar in many types of drinks and processed foods, especi...
ORGANISM(S): Rattus norvegicus (Rat) 
2023-03-11 | PXD038834 | Pride
Hypothalamus Proteomics Mitochondria Inflammation. Adolescence Fructose-rich diet 
ProteomicsAging-related proteome alterations in B cells may predispose for chronic lymphocytic leukemia - nuclear proteins of elderly B cells
Chronic lymphocytic leukemia (CLL), the most common type of leukemia in adults, is still incurable despite the development of novel therapeutic strategies. This reflects the incomplete understanding of the pathophysiology of this disease. In order to get more detailed insights into CLL development, ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000082941 | MassIVE
UnknownPhysical activity practiced at a young age is associated with a less severe subsequent clinical presentation in facioscapulohumeral muscular dystrophy.
Not available
S-EPMC10768364 | biostudies-literature
ProteomicsHUMAN PLASMAS FROM ELDERLY PEOPLE DISPLAY A PROTEIN SIGNATURE SUGGESTIVE OF A CHRONIC INFLAMMATORY STATE
Blood from elderly individuals exhibits a reduced "rejuvenating" effect compared to that of young donors, and plasma from older subjects used as a supplement in cell culture media is less effective than plasma from younger individuals. A mass spectrometry-based proteomic analysis of plasma samples f...
ORGANISM(S): Homo sapiens (Human) 
2026-02-02 | PXD063248 | Pride
Ms spectrometry (ms) Aging Inflammaging Plasma proteome Immune senescence 
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