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Metabolomics13C glucose labelling studies using 2D NMR is a useful tool for determining ex vivo whole organ metabolism during hypothermic machine perfusion of kidneys
Background: The aim of this study is to determine the feasibility of using Nuclear Magnetic Resonance (NMR) tracer studies (13C-enriched glucose) to detect ex vivo de novo metabolism in the perfusion fluid and cortical tissue of porcine kidneys during hypothermic machine perfusion (HMP). Methods: Po...
2017-10-16 | MTBLS367 | MetaboLights
ProteomicsBleomycin model of fibrosis and resolution phase in old and young mice
Bleomycin-induced pulmonary fibrosis in mice mimics major hallmarks of idiopathic pulmonary fibrosis, yet in this model it spontaneously resolves over time. We studied molecular mechanisms of fibrosis resolution and lung repair, focusing on transcriptional and proteomic signatures and the effect of ...
ORGANISM(S): Mus musculus (Mouse) 
2023-08-09 | PXD041050 | Pride
Bleomycin Dia Mouse Lung Fibrosis Age 
ProteomicsBleomycin model of fibrosis and resolution phase in old and young mice
Bleomycin-induced pulmonary fibrosis in mice mimics major hallmarks of idiopathic pulmonary fibrosis, yet in this model it spontaneously resolves over time. We studied molecular mechanisms of fibrosis resolution and lung repair, focusing on transcriptional and proteomic signatures and the effect of ...
ORGANISM(S): Mus musculus (Mouse) 
2024-09-10 | PXD040530 | Pride
Bleomycin Dia Mouse Lung Fibrosis Age 
MetabolomicsMetabolically-incorporated deuterium in myelin localized by neutron diffraction and identified by mass spectrometry
Myelin is a natural and dynamic multilamellar membrane structure that continues to be of significant biological and neurological interest, especially with respect to its biosynthesis and assembly during its normal formation and maintenance, and pathological breakdown. To explore the usefulness of ne...
2024-09-27 | MTBLS4717 | MetaboLights
TranscriptomicsGene expression and H3K27 tri-methylation analysis of meristematic tissue (Me) and young leaves (Le) isolated by manual dissection of clv3-9 plants
This SuperSeries is composed of the following subset Series: GSE24464: Expression analysis of meristematic tissue (Me) and young leaves (Le) isolated by manual dissection of clv3-9 plants GSE24474: H3K27 tri-methylation analysis of meristematic tissue (Me) and young leaves (Le) isolated by manual di...
ORGANISM(S): Arabidopsis thaliana 
2011-04-20 | E-GEOD-24507 | biostudies-arrayexpress
UnknownHigher Virulence of Diplodia seriata Isolates on Vines of cv. Cabernet Sauvignon Associated with 10-Year-Old Wood Compared to Young Tissue.
Not available
S-EPMC10459257 | biostudies-literature
TranscriptomicsH3K27 tri-methylation analysis of meristematic tissue (Me) and young leaves (Le) isolated by manual dissection of clv3-9 plants
For the histone methylation analysis of undifferentiated and differentiated tissues a meristem enriched fraction and young leaves (up to 3 mm leaf blade length) were isolated from clavata3-9 plants. Clavata3-9 mutants harbour larger shoot apical meristems than wild type plants enabling the preparati...
ORGANISM(S): Arabidopsis thaliana 
2011-03-21 | E-GEOD-24474 | biostudies-arrayexpress
ProteomicsProteomic profiling of young and old mice in the bleomycin model
The most preclinical used in vivo model to study lung fibrosis is the bleomycin-induced lung fibrosis model in 2-3-month-old mice. Although this model resembles key aspects of idiopathic pulmonary fibrosis (IPF), there are limitations in its predictability for the human disease. One of the main diff...
ORGANISM(S): Mus musculus (Mouse) 
2024-09-10 | PXD026222 | Pride
Bleomycin Idiopathic pulmonary fibrosis Tmt Fusion lumos Lc-ms Lung Sps ms3 C57bl/6j mouse 
MetabolomicsThe HuMet Repository: Watching human metabolism at work
Metabolism oscillates between catabolic and anabolic states depending on food intake, exercise, or stresses that change a multitude of metabolic pathways simultaneously. We present the HuMet Repository for exploring dynamic metabolic responses to oral glucose/lipid loads, mixed meals, 36-h fasting, ...
2024-07-23 | MTBLS89 | MetaboLights
ProteomicsHippocampal circadian proteomes of young and middle-aged mice
Hippocampal tissues from young and middle-aged C57BL/6J mice were harvested at 4-hour intervals over two days and processed for proteomic analysis using label-free quantification.
ORGANISM(S): Mus musculus (Mouse) 
2020-05-26 | PXD013364 | Pride
Circadian Hippocampus Proteomics Mouse Lc-ms/ms 
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