Sort   by:  
 Page size 
MetabolomicsFaecal microbiota transplant from aged donor mice affects spatial learning and memory via modulating hippocampal synaptic plasticity- and neurotransmission-related proteins in young recipients

BACKGROUND: The gut-brain axis and the intestinal microbiota are emerging as key players in health and disease. Shifts in intestinal microbiota composition affect a variety of systems, however, evidence of their direct impact on cognitive functions is still lacking. We tested whe...

2021-12-17 | MTBLS1437 | MetaboLights
MetabolomicsDiel metabolomics analysis of a hot spring chlorophototrophic microbial mat leads to new hypotheses of community member metabolisms
Dynamic environmental factors such as light, nutrients, salt, and temperature continuously affect chlorophototrophic microbial mats, requiring adaptive and acclimative responses to stabilize composition and function. Quantitative metabolomics analysis can provide insights into metabolite dynamics fo...
2024-02-23 | MTBLS187 | MetaboLights
ProteomicsReduced insulin/IGF-1 signaling restores the dynamic properties of key stress granule proteins during aging
Low complexity “prion-like” domains in key RNA-binding proteins (RBPs) mediate the reversible assembly of RNA granules. Individual RBPs harboring these domains have been linked to specific neurodegenerative diseases. Although their aggregation in neurodegeneration has been extensively characterized,...
ORGANISM(S): Caenorhabditis elegans 
2017-01-16 | PXD003451 | Pride
Caenorhabditis elegans Itraq Quantification Aging Insulin Aggregation 
UnknownEvidence That Leonardo da Vinci Had Strabismus.
Not available
S-EPMC6439801 | biostudies-literature
MetabolomicsTreatment of lean and diet-induced obesity (DIO) mice with a novel stable obestatin analogue alters plasma metabolite levels as detected by untargeted LC-MS metabolomics
Introduction: Obestatin is a controversial gastrointestinal peptide purported to have metabolic actions. Objectives: This study investigated whether treatment with a stable obestatin analogue (PEG-OB(Cys10, Cys13) changed plasma metabolite levels firstly in lean and subsequently in diet-induced obes...
2017-07-25 | MTBLS334 | MetaboLights
TranscriptomicsExpression response of human monocyte derived macrophages to dexamethasone over a 24h time series
Macrophages are amongst the major targets of glucocorticoids (GC) as therapeutic anti-inflammatory agents. Here we show that GC treatment of mouse and human macrophages initiates a cascade of induced gene expression including many anti-inflammatory genes. Inducible binding of the glucocorticoid rec...
ORGANISM(S): Homo sapiens 
2015-12-17 | E-GEOD-61880 | biostudies-arrayexpress
UnknownLoss of cystic fibrosis transmembrane conductance regulator function produces abnormalities in tracheal development in neonatal pigs and young children.
Not available
S-EPMC3001264 | biostudies-literature
TranscriptomicsExpression data from a 24h time series of dexamethasone treatment for mouse bone marrow derived macrophages
Macrophages are amongst the major targets of glucocorticoids (GC) as therapeutic anti-inflammatory agents. Here we show that GC treatment of mouse and human macrophages initiates a cascade of induced gene expression including many anti-inflammatory genes. Inducible binding of the glucocorticoid rec...
ORGANISM(S): Mus musculus 
2015-12-17 | E-GEOD-61879 | biostudies-arrayexpress
UnknownLGBQ-affirmative cognitive-behavioral therapy for young gay and bisexual men's mental and sexual health: A three-arm randomized controlled trial.
Not available
S-EPMC9446477 | biostudies-literature
UnknownTime to Gender-Affirming Hormone Therapy Among US Military-Affiliated Adolescents and Young Adults.
Not available
S-EPMC11334009 | biostudies-literature
Sort   by:  
 Page size