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TranscriptomicsGenome-wide polysome analysis in poly(I:C)-treated WT and Oasl1-/- BMDM.
OASL1 is a novel translation inhibitor for the type I IFN master transcription factor IRF7. To examine whether OASL1 specifically inhibit IRF7 translation, we used a genome-wide gene expression microarray to screen for the polysome-associated mRNAs more enriched in the OASL1 KO BMDMs. The microarray...
ORGANISM(S): Mus musculus 
2013-02-17 | E-GEOD-41787 | biostudies-arrayexpress
TranscriptomicsRevisiting Global Gene Expression Analysis (RNA-Seq)
Gene expression analysis is a widely used and powerful method for investigating the transcriptional behavior of biological systems, for classifying cell states in disease and for many other purposes. Recent studies indicate that common assumptions currently embedded in experimental and analytical p...
ORGANISM(S): Homo sapiens 
2012-10-25 | E-GEOD-40783 | biostudies-arrayexpress
TranscriptomicsDevelopmental timecourse of C. elegans small RNAs with 5p monophosphates
These datasets profile the expression of small RNAs with 5p monophosphates and 3p hydroxyls (including miRNAs, 21U-RNAs) across C. elegans development and in dauer, glp-4 mutant, and mixed-stage wt worms. These datasets were prepared in the David P. Bartel laboratory using T4 RNA ligase Rnl2(1-249)....
ORGANISM(S): Caenorhabditis elegans 
2008-06-15 | E-GEOD-11734 | biostudies-arrayexpress
TranscriptomicsCorrelates of chronic stress and their influence on the development of substance use in a population-based cohort of young adults (OYSUP)
Background: We seek to understand correlates of chronic stress and their influence on the development of substance use in a population-based cohort of young adults (OYSUP). Methodology: We evaluated clinical features, salivary RNA metrics and differential expression of candidate genes in unfraction...
ORGANISM(S): Homo sapiens 
2012-06-15 | E-GEOD-27144 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human breast tumors to identify age-specific differences of oncogenic pathway deregulation
Breast cancer arising in young women has a poorer prognosis, is less likely to be hormone sensitive, and represents a particularly challenging clinical entity. The biology driving the aggressive nature of breast cancer arising in young women has yet to be defined. Among 784 patients with early stag...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-7849 | biostudies-arrayexpress
GenomicsChromatin Immunoprecipitation of TRA-1 in C. elegans and C. briggsae
The goal of this study is to identify and characterize sites in the C. elegans genome bound by the transcription factor TRA-1. TRA-1 ChIP-seq was performed in the following stages of animals in duplicate: 1) L2 stage of C. elegans wild-type N2 strain; 2) L3 stage of C. elegans wild-type N2 strain; 3...
ORGANISM(S): Caenorhabditis briggsae 
2013-11-04 | E-GEOD-48917 | biostudies-arrayexpress
UnknownEvaluating the use of oral pre-exposure prophylaxis among pregnant and postpartum adolescent girls and young women in Cape Town, South Africa.
Not available
S-EPMC10546059 | biostudies-literature
TranscriptomicsCorrelation of Candidate Genetic Variations for Susceptibility and Risk Assessment of Type 2 Diabetes Mellitus and its Related Medical Conditions among Filipinos (DM2)
Various studies have established the role of genetics in the development of type 2 diabetes mellitus (T2DM) across population groups with a reported heritability of 30–70%. These studies highlight the effect of interethnic variability in genetic susceptibility and risk for complications of T2DM. The...
ORGANISM(S): Homo sapiens 
2026-09-01 | E-MTAB-17412 | biostudies-arrayexpress
TranscriptomicsCorrelation of Candidate Genetic Variations for Susceptibility and Risk Assessment of Type 2 Diabetes Mellitus and its Related Medical Conditions among Filipinos (DM2)
Various studies have established the role of genetics in the development of type 2 diabetes mellitus (T2DM) across population groups with a reported heritability of 30–70%. These studies highlight the effect of interethnic variability in genetic susceptibility and risk for complications of T2DM. The...
ORGANISM(S): Homo sapiens 
2026-09-01 | E-MTAB-17413 | biostudies-arrayexpress
TranscriptomicsAMPK governs lineage specification through Tfeb-dependent regulation of lysosomes
Faithful execution of developmental programs relies on the acquisition of unique cell identities from pluripotent progenitors, a process governed by combinatorial inputs from numerous signaling cascades that ultimately dictate lineage-specific transcriptional outputs. Despite growing evidence that m...
ORGANISM(S): Mus musculus 
2016-03-09 | E-GEOD-77705 | biostudies-arrayexpress
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