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TranscriptomicsA Parallel Study of mRNA and MicroRNA Profiling of Peripheral Blood in Young Adult Women
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2013-08-13 | E-GEOD-30205 | biostudies-arrayexpress
TranscriptomicsGenomic profiling of type-1 adult diabetic and aged normoglycemic mice liver
Here we characterized and compared differential gene expression from diabetic and normoglycemic NOD mice and from aged and young-adults Balb/c mice. Total RNA from NOD diabetic (3 weeks with glicemia over 500mg/dl) and normoglycemic NOD mice from the same age was used. To compare the effects of agin...
ORGANISM(S): Mus musculus 
2013-09-06 | E-GEOD-50613 | biostudies-arrayexpress
TranscriptomicsIdentification of BORIS-bound transcripts in neural progenitor cells and young neurons
This study compares the transcripts bound to BORIS in neural progenitor cells and cells differentiated for 6 days into young neurons We present expression profiles for neural progenitor cells (arrays hybridised in triplicate) and in young neurons (arrays hybridised in duplicate). Immunoprecipitated ...
ORGANISM(S): Homo sapiens 
2013-11-29 | E-GEOD-42294 | biostudies-arrayexpress
TranscriptomicsNeonatal beta cells lack the specialized metabolic phenotype of mature beta cells
Fetal and neonatal beta cells have poor glucose-induced insulin secretion and only gain robust glucose responsiveness several weeks after birth. This unresponsiveness may be due to a generalized immaturity of the metabolic pathways normally found in beta cells. Gene expression profile of neonatal (1...
ORGANISM(S): Rattus norvegicus 
2011-02-22 | E-GEOD-24790 | biostudies-arrayexpress
Transcriptomicshcf-1(-) transcriptional profiling
We used microarrays to identify genes regulated by HCF-1 in a daf-16-dependent manner. Samples from young adult worms were hybridized to Agilent microarrays to identify genes differentially expressed in hcf-1(pk924)/daf-16(mgDf47);hcf-1(pk924) and compared to hcf-1(pk924)/N2 arrays.
ORGANISM(S): Caenorhabditis elegans 
2011-07-22 | E-GEOD-30725 | biostudies-arrayexpress
TranscriptomicsExpression data in PD-L1 positive and PD-L1 negative human melanoma samples
Blocking the PD-1/PD-L1 immunosuppressive pathway has shown promise in the treatment of certain cancers including melanoma. This study investigates differences in the gene expression profiles of human melanomas that do or do not display the immunosuppressive protein PD-L1. Further understanding of g...
ORGANISM(S): Homo sapiens 
2015-05-01 | E-GEOD-65041 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat dentate gyrus of the hippocampus from young and aged rats to identification of putative learning and memory genes following the Morris Water Maze
The aim of this study was to investigate whether the differences in memory decline associated with aging are a result of differences in gene expression. We first categorized age-unimpaired and age-impaired rats based on their performance in the Morris water maze, when compared to young rats. Then w...
ORGANISM(S): Rattus norvegicus 
2008-06-13 | E-GEOD-4821 | biostudies-arrayexpress
TranscriptomicsYoung and old HSCs from WT and Lnk-/- mice
The adaptor protein Lnk is an important negative regulator of HSC homeostasis and self-renewal. This study aims to investigate the role of Lnk in HSC aging. Here we performed expression profiling of bone marrow CD150+CD48-LSK LT-HSCs from young and old WT and Lnk-/- mice. Results identify select Lnk...
ORGANISM(S): Mus musculus 
2012-10-03 | E-GEOD-39553 | biostudies-arrayexpress
TranscriptomicsGermline and embryo gene expression of wild-type vs. mutants in lin-54, a component of the C. elegans DRM complex
DRM is a conserved transcription factor complex that includes E2F/DP and pRB family proteins and plays important roles in development and cancer. Here we perform microarray expression profiling analysis of lin-54, a DNA-binding member of the DRM complex. To identify genes regulated by LIN-54 in soma...
ORGANISM(S): Caenorhabditis elegans 
2011-04-09 | E-GEOD-28494 | biostudies-arrayexpress
TranscriptomicsChromosome-biased binding and gene regulation by the C. elegans DRM complex
This SuperSeries is composed of the following subset Series: GSE28494: Germline and embryo gene expression of wild-type vs. mutants in lin-54, a component of the C. elegans DRM complex GSE28852: Chromosome-biased binding and gene reguation by the C. elegans DRM complex [ChIP-chip] Refer to individua...
ORGANISM(S): Caenorhabditis elegans 
2011-04-27 | E-GEOD-28853 | biostudies-arrayexpress
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