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TranscriptomicsNeonatal beta cells lack the specialized metabolic phenotype of mature beta cells
Fetal and neonatal beta cells have poor glucose-induced insulin secretion and only gain robust glucose responsiveness several weeks after birth. This unresponsiveness may be due to a generalized immaturity of the metabolic pathways normally found in beta cells. Gene expression profile of neonatal (1...
ORGANISM(S): Rattus norvegicus 
2011-02-22 | E-GEOD-24790 | biostudies-arrayexpress
TranscriptomicsStrome HK00001_H3K36ME3_13C9_N2_YA_s7
modENCODE_submission_3559 This submission comes from a modENCODE project of Jason Lieb. For full list of modENCODE projects, see http://www.genome.gov/26524648 Project Goal: The focus of our analysis will be elements that specify nucleosome positioning and occupancy, control domains of gene expressi...
ORGANISM(S): Caenorhabditis elegans 
2012-04-22 | E-GEOD-37512 | biostudies-arrayexpress
TranscriptomicsStrome WA30534819_H3K4ME3_N2_YA_s7
modENCODE_submission_3552 This submission comes from a modENCODE project of Jason Lieb. For full list of modENCODE projects, see http://www.genome.gov/26524648 Project Goal: The focus of our analysis will be elements that specify nucleosome positioning and occupancy, control domains of gene expressi...
ORGANISM(S): Caenorhabditis elegans 
2012-04-22 | E-GEOD-37505 | biostudies-arrayexpress
TranscriptomicsThe Influence of Sleep Deprivation on Hippocampal CA1 Gene Expression: Relation to Stress and Aging
Sleep deprivation (SD) in young adults is associated with metabolic, stress and cognitive responses that are also characteristic of brain aging. Given that sleep architecture changes with age, including increased fragmentation and decreased slow wave activity, it seems reasonable to investigate pote...
ORGANISM(S): Rattus norvegicus 
2012-07-16 | E-GEOD-34424 | biostudies-arrayexpress
GenomicsRecruitment of RNA Polymerase II by the pioneer transcription factor PHA-4
Using staged embryos, we find many more genes with poised RNA polymerase than had been observed previously in C. elegans embryos, suggesting that early embryos accumulate poised PolII, and that poising is dynamic. Embryos were staged at the 8E and Bean stages of development prior to ChIP-seq
ORGANISM(S): Caenorhabditis elegans 
2015-07-01 | E-GEOD-68280 | biostudies-arrayexpress
UnknownFeasibility of a co-designed and personalised intervention to improve vegetable intake in rural-dwelling young adults.
Not available
S-EPMC12257653 | biostudies-literature
TranscriptomicsBiological Aging and Circadian Mechanisms in Murine Brown Adipose Tissue, Inguinal White Adipose Tissue, and Liver (Nov 2009 dataset)
The circadian profile of the transcriptomes in murine tissues was compared between groups of young and old male mice. The oscillatory phase and absolute expression levels were evaluated as a function of biological age. Distinct differences in multiple pathways were apparent based on biological and c...
ORGANISM(S): Mus musculus 
2012-03-15 | E-GEOD-25323 | biostudies-arrayexpress
TranscriptomicsBiological Aging and Circadian Mechanisms in Murine Brown Adipose Tissue, Inguinal White Adipose Tissue, and Liver (Jan 2010 dataset)
The circadian profile of the transcriptomes in murine tissues was compared between groups of young and old male mice. The oscillatory phase and absolute expression levels were evaluated as a function of biological age. Distinct differences in multiple pathways were apparent based on biological and c...
ORGANISM(S): Mus musculus 
2012-03-15 | E-GEOD-25324 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse side-population sorted putative intestinal stem cells.
While the existence of intestinal epithelial stem cells (IESCs) has been well established, their study has been limited due to the inability to isolate them. Previous work has utilized side population (SP) sorting of the murine small intestinal mucosa to isolate a viable fraction of cells enriched ...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-9013 | biostudies-arrayexpress
TranscriptomicsGenetic Susceptibility to Diabetic Nephropathy is Related to Pro-inflammatory Pathways
Diabetic nephropathy (DN) is a leading cause of ESRD worldwide, but its molecular pathogenesis is not well-defined and there are no specific treatments. In humans, there is a strong genetic component determining susceptibility to DN. However, specific genes controlling DN susceptibility in humans ha...
ORGANISM(S): Mus musculus 
2016-08-13 | E-GEOD-85569 | biostudies-arrayexpress
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