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ProteomicsYTHDF1 links hypoxia adaptation and non-small cell lung cancer progression
10plex TMT labelling quantification expriments were performed to access the knockdown effect of YTHDF1 in cells.3 shGFPs control samples, 3 YTHDF1 shRNA-2 knockdown samples , 3 YTHDF1 shRNA-3 knockdown samples and 1 mixture sample were labelled by TMT 10-plex reagents.
ORGANISM(S): Homo sapiens (Human) 
2019-09-27 | PXD015182 | Pride
Lc-ms/ms tmt10plex 
ProteomicsQuantitative proteomic analysis of mouse cerebellar granule cells after knockdown of YTHDF1
To identify the target mRNAs of YTHDF1 in granule cells, we performed quantitative proteomic analysis. Mouse cerebellar granule cells were cultured and infected with lentiviral shYthdf1 or shCtrl. Proteins were extracted. After further processing, TMT-labeled peptides were subjected to LC-MS/MS anal...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-15 | PXD019249 | Pride
Ythdf1  ythdf2  local translation 
ProteomicsUSP5 Stabilizes YTHDF1 to Control Cancer Immune Surveillance through mTORC1-mediated Phosphorylation
The N6-methyladenosine (m6A) binding protein YTHDF1 emerges as a frequently upregulated oncogene across various cancer types. Its depletion significantly improves the efficacy of cancer immune checkpoint blockade (ICB) treatment. A comprehensive understanding of the molecular mechanisms governing YT...
ORGANISM(S): Homo Sapiens 
2024-11-14 | PXD057917 |
Proteomicsidentification of the altered protein between wildtype and YTHDF1 knockout B16/F10 using Tandem Mass Tag
The recently described role of RNA methylation in regulating immune cell infiltration into tumors has attracted interest, given its potential impact on immunotherapy response. YTHDF1 is a versatile and powerful m6A reader, but the understanding of its impact on immune evasion is limited. Here, we pe...
ORGANISM(S): Mus musculus (Mouse) 
2022-12-06 | PXD036931 | Pride
Tmt B16/f10 Ythdf1 
ProteomicsMettl3-m6A-YTHDF1 axis promotion of mitochondrial dysfunction in metabolic dysfunction–associated steatotic liver disease (MASLD)
The N6-methyladenosine (m6A) mRNA modification and the mitochondrial respiratory chain (MRC) hold paramount importance in the advancement of MASLD. This study thoroughly investigates the relationship and impact of m6A mRNA modification and mitochondrial function in the progression of MASLD. Here we ...
ORGANISM(S): Mus musculus (Mouse) 
2024-09-20 | PXD047819 | Pride
M6a mettl3 mitochondria masld ythdf1 
GenomicsFMRP phosphorylation modulates neuronal translation through YTHDF1
FMRP phosphorylation modulates neuronal translation through YTHDF1
PRJNA887460 | ENA
Genomicsm6A-facilitated hippocampal learning and memory through Ythdf1
m6A-facilitated hippocampal learning and memory through Ythdf1
PRJNA417392 | ENA
GenomicsAnti-YTHDF1 and anti-YTHDF2 RIP-Seq to identify the target mRNAs for YTHDF1 and YTHDF2, respectively
Anti-YTHDF1 and anti-YTHDF2 RIP-Seq to identify the target mRNAs for YTHDF1 and YTHDF2, respectively
PRJNA643706 | ENA
GenomicsYTHDF1-N6-methyladenosine-ARHGEF2 axis promoted colorectal tumorigenesis and metastasis
YTHDF1-N6-methyladenosine-ARHGEF2 axis promoted colorectal tumorigenesis and metastasis
PRJNA668907 | ENA
Genomicsm6A sequences 2 WT_input vs 2 Ythdf1 KO_input
m6A sequences 2 WT_input vs 2 Ythdf1 KO_input
PRJNA1185384 | ENA
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