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ProteomicsFam20C interactome in the secretory pathway under ER stress
Accumulated unfolded proteins in the endoplasmic reticulum (ER) will trigger the unfolded protein response (UPR) to increase protein-folding capacity. The ER proteostasis and UPR signaling should be precisely and timely regulated. In the project, by unbiased proteomics analysis, we identify that the...
ORGANISM(S): Homo sapiens (Human) 
2020-03-02 | PXD016619 | Pride
Fam20c Pdi Er stress Phosphorylation 
ProteomicsFam20C-LCMSMS - Secretory kinase Fam20C tunes endoplasmic reticulum redox state via phosphorylation of Ero1α
Family with sequence similarity 20C (Fam20C), the physiological Golgi casein kinase, phosphorylates numerous secreted proteins that are involved in a wide variety of biological processes. However, the role of Fam20C in regulating proteins in the endoplasmic reticulum (ER) lumen is largely unknown. H...
ORGANISM(S): Homo sapiens (Human) 
2018-05-30 | PXD009333 | Pride
Fam20c ero1 lcmsms 
ProteomicsThe effects of enzalutamide on androgen-dependent and androgen-independent prostate cancer cells.
To investigate the mechanisms of drug resistance and castration resistance in prostate cancer, we performed proteomic sequencing on androgen-dependent prostate cancer cells (LNCaP) and androgen-independent cells (AI) treated with enzalutamide.
ORGANISM(S): Homo Sapiens 
2024-11-26 | PXD058261 |
ProteomicsStudy of biological function of VRK1 in the development and progress of prostate cancer
VRK1 plays a significant role in the growth and drug resistance of prostate cancer.
ORGANISM(S): Homo Sapiens 
2024-11-22 | PXD058205 |
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