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MetabolomicsContributions of the Microbiome-Derived Metabolome for Risk Assessment and Prognostication of Pancreatic Cancer

BACKGROUND Increasing evidence implicates microbiome involvement in the development and progression of pancreatic ductal adenocarcinoma (PDAC). Studies suggest that reflux of gut or oral microbiota can lead to colonization in the pancreas, resulting in dysbiosis that culminates ...

2023-08-09 | MTBLS7260 | MetaboLights
ProteomicsIdentification of Escherichia coli FH-binding proteins
This project used biotin pull-down to screen membrane proteins with FH binding function from the membrane proteins of Escherichia coli RS218. It contained an experimental group (SHIYANZU1) and a control group (DUIZHAOZU)..
ORGANISM(S): Escherichia Coli Rs218 
2020-07-23 | PXD020521 |
TranscriptomicsTranscription profiling by array of human benign prostate, primary and metastatic prostate cancer samples to reveal signatures of metastatic progression
An integrative analysis of this compendium of proteomic alterations and transcriptomic data was performed revealing only 48-64% concordance between protein and transcript levels. Importantly, differential proteomic alterations between metastatic and clinically localized prostate cancer that mapped c...
ORGANISM(S): Homo sapiens 
2005-09-20 | E-GEOD-3325 | biostudies-arrayexpress
ProteomicsNovel Mechanism and Therapy of Anthracycline-Induced Cardiotoxicity (AIC)
Anthracyclines are potent chemotherapeutic agents known for their efficacy in treating various cancers via inhibition of topoisomerase II alpha (TOP2A). However, their clinical use is limited due to cardiotoxicity, primarily attributed to off-target inhibition of topoisomerase II beta (TOP2B) in car...
ORGANISM(S): Mus musculus (Mouse) 
2026-05-05 | PXD077277 | Pride
Top2b Smyd1 
MetabolomicsHuman umbilical cord-derived mesenchymal stem cells ameliorate perioperative neurocognitive disorder by inhibiting inflammatory responses and activating BDNF/TrkB/CREB signaling pathway in aged mice

BACKGROUND: Perioperative neurocognitive disorder (PND) is a key complication affecting older individuals after anesthesia and surgery. Failure to translate multiple pharmacological therapies for PND from preclinical studies to clinical settings has necessitated the exploration o...

2023-07-25 | MTBLS7759 | MetaboLights
Genomicsena-DATASET-MDACC-20-08-2014-16:58:44:853-680 - samples
This is the targeted capture deep sequencing (TCS) data for validation of the mutations discovered in the WES step. There are 58 bam files of TCS data including 48 tumor samples and 10 peripheral blood WBC samples.
EGAD00001000985 | EGA
Genomicsena-DATASET-MDACC-20-08-2014-16:52:57:923-677 - samples
This is the Whole Exome Sequencing (WES) data from 59 samples from 11 patients with lung adenocarcinomas including 48 tumor samples and 11 peripheral white blood cell samples
EGAD00001000984 | EGA
GenomicsIntra-tumor heterogeneity of localized lung adenocarcinomas defined by multi-region sequencing
Background: Intra-tumor heterogeneity (ITH) may have profound impacts on biopsy strategy, characterization of actionable targets, treatment planning, and drug resistance. ITH of lung cancers has not been well studied. Methods: We performed multi-region whole exome sequencing (average sequencing de...
EGAS00001000930 | EGA
GenomicsAndy Futreal
Data Access Committee EGAC00001000223
EGAC00001000223 | EGA
ProteomicsMass spectrum data for the manuscript "Mitochondriomics reveals the underlying neuoprotective mechanism of TrkB receptor agonist R13 in the 5xFAD mice"
This is the original mass spectrometry data, which includes 45 mass spectra data and a search database table. All these data and sample processing methods can refer to the ca in the manuscript
ORGANISM(S): Mus Musculus 
2021-02-19 | PXD024268 |
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