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TranscriptomicsAmitriptyline-mediated cognitive enhancement in aged 3xTg Alzheimer’s disease mice is associated with neurogenesis and neurotrophic activity
Approximately 35 million people worldwide suffer from Alzheimer’s disease (AD). Existing therapeutics, while moderately effective, are currently unable to stem the widespread rise in AD prevalence. AD is associated with an increase in amyloid beta (A) oligomers and hyperphosphorylated tau, along wit...
ORGANISM(S): Mus musculus 
2011-12-31 | E-GEOD-26836 | biostudies-arrayexpress
UnknownFar-Infrared Radiation Ameliorates the Cognitive Dysfunction in an Alzheimer's Disease Transgenic Mouse via Modulating Jak-2/Stat3 and Nrf-2/HO-1 Pathways.
Not available
S-EPMC12081534 | biostudies-literature
UnknownNeuroprotective effect of Notch pathway inhibitor DAPT against focal cerebral ischemia/reperfusion 3 hours before model establishment.
Not available
S-EPMC6334612 | biostudies-literature
UnknownRecurrent mutations in topoisomerase IIα cause a previously undescribed mutator phenotype in human cancers.
Not available
S-EPMC8795545 | biostudies-literature
UnknownEndoplasmic reticulum stress is involved in retinal injury induced by repeated transient spikes of intraocular pressure.
Not available
S-EPMC8435347 | biostudies-literature
UnknownBaicalin alleviates sepsis-associated acute kidney injury through activation of the PPAR-γ/UCP1 signaling pathway.
Not available
S-EPMC12168399 | biostudies-literature
MetabolomicsStudy on the mechanism of p-hydroxybenzyl alcohol against OGD/R damage based on metabonomic analysis

Gastrodia elata Blume (GE) has been widely used to treat various central and peripheral nerve diseases, and P-Hydroxybenzaldehyde (PHBA) is one of the indicative components of GE brain protection. Since the previous study of our group found that PHBA has a good effect on protecting mitoc...

2024-07-04 | MTBLS7870 | MetaboLights
UnknownIdentification of compound CA-5f as a novel late-stage autophagy inhibitor with potent anti-tumor effect against non-small cell lung cancer.
Not available
S-EPMC6351124 | biostudies-literature
UnknownAstragaloside IV alleviates heart failure by regulating SUMO-specific protease 1.
Not available
S-EPMC8355636 | biostudies-literature
UnknownElectroacupuncture enhances the mitophagy of granulosa cells in premature ovarian insufficiency model mice by inactivating the hippo-yes-associated protein/transcriptional co-activator with postsynaptic density protein, drosophila disc large tumor suppressor, and zonula occludens-1 protein binding motif pathway.
Not available
S-EPMC11764945 | biostudies-literature
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