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TranscriptomicsA large-scale clinical study of gene expression response to severe burn injury
To understand the age-dependent response to burn injury, blood samples from pediatric and adult patients were collected at different times after severe burn injury. Gene expression was measured using Affymetrix U133 Plus 2.0 arrays for both patient samples and healthy controls. Time points were binn...
ORGANISM(S): Homo sapiens 
2010-06-16 | E-GEOD-19743 | biostudies-arrayexpress
TranscriptomicsA genome-wide transcriptome analysis reveals diverse roles of two-component system DraR-K in physiological and morphological differentiation of Streptomyces coelicolor
A novel two-component system (TCS) DraR-K was identified previously to play a differential role in antibiotic biosynthesis (ACT, RED and yCPK) of Streptomyces coelicolor M145 on defined minimal medium (MM) conditions. In order to assess whether DraR-K has more global roles, a genome-wide transcripto...
ORGANISM(S): Streptomyces coelicolor 
2014-03-10 | E-GEOD-55714 | biostudies-arrayexpress
UnknownUpregulation of carbonic anhydrase 1 beneficial for depressive disorder.
Not available
S-EPMC10071615 | biostudies-literature
TranscriptomicsResponsive genes upon deletion of the ohkA gene in Streptomyces coelicolor M145
Transcription profile analysis between the wild-type strain M145 and the ohkA-deletion mutant to determine the overall transcription changes caused by the deletion of orphan histidine kinase gene ohkA in S.coelicolor. Transcription changes between the ohkA mutant and the wild-type strain M145 were p...
ORGANISM(S): Streptomyces coelicolor A3(2) 
2011-01-05 | E-GEOD-26426 | biostudies-arrayexpress
UnknownAn autoimmune pleiotropic SNP modulates IRF5 alternative promoter usage through ZBTB3-mediated chromatin looping.
Not available
S-EPMC9984425 | biostudies-literature
TranscriptomicsA long noncoding RNA protects the heart from pathological hypertrophy
The role of long noncoding RNA (lncRNA) in adult hearts is unknown; also unclear is how lncRNA modulates nucleosome remodelling. An estimated 70% of mouse genes undergo antisense transcription1, including myosin heavy chain 7 (Myh7), which encodes molecular motor proteins for heart contraction2. Her...
ORGANISM(S): Homo sapiens 
2014-08-05 | E-GEOD-49716 | biostudies-arrayexpress
ProteomicsA chemical screen identifies PRMT5 as a therapeutic vulnerability for paclitaxel-resistant triple-negative breast cancer
Through chemical probe screening, we uncovered a novel mechanism of RNA splicing in paclitaxel-resistant TNBC and identified PRMTs as therapeutic targets.
ORGANISM(S): Homo Sapiens 
2024-06-22 | PXD053336 |
ProteomicsProteomics comparison of protein changes in H1299 cell before and after resistance to cdk4/6 inhibitors
This is the raw proteomics data of H1299 cell before and after resistance to cdk4/6 inhibitors
ORGANISM(S): Homo Sapiens 
2023-05-15 | PXD042216 |
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