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MetabolomicsAbsence of tmRNA Increases the Persistence to Cefotaxime and the Intercellular Accumulation of Metabolite GlcNAc in Aeromonas veronii
Bacterial persisters are a small proportion of phenotypically heterogeneous variants with the transient capability to survive in high concentrations of antibiotics, causing recurrent infections in both human and aquatic animals. Transfer-messenger RNA (tmRNA), which was encoded by the ssrA ge...
2021-10-18 | MTBLS1182 | MetaboLights
MetabolomicsButyrate epigenetically licenses sustained epithelial-T cell crosstalk for intestinal immune tolerance

Butyrate, one of the most abundant microbial-derived metabolites in the gut, is important in regulating intestinal homeostasis. In this study, we used untargeted global metabolomics to landscape the intestinal epithelial cellular metabolites changed by butyrate treatment.

2026-06-26 | MTBLS14301 | MetaboLights
UnknownDiscovery of Imidazoisoindole Derivatives as Highly Potent and Orally Active Indoleamine-2,3-dioxygenase Inhibitors.
Not available
S-EPMC6580535 | biostudies-literature
TranscriptomicsA genomic approach to bud mutation in sweet orange (Citrus sinensis L. Osbeck) fruit
Bud mutations arise often in citrus. The selection of mutants is one of the most important breeding methods in citrus. However, the molecular bases of bud mutation have rarely been studied. To identify the potential important or novel genes involved in bud mutation, different transcriptomic techniqu...
ORGANISM(S): Citrus sinensis 
2009-03-09 | E-GEOD-10729 | biostudies-arrayexpress
TranscriptomicsRNA Polymerase II-associated factor 1 regulates the release and phosphorylation of paused RNA Polymerase II
Release of promoter-proximal paused RNA polymerase II (Pol II) during early elongation is a critical step in transcriptional regulation in metazoan cells. Paused Pol II release is thought to require the kinase activity of cyclin-dependent kinase 9 (CDK9) for the phosphorylation of DRB sensitivity-in...
ORGANISM(S): Homo sapiens 
2015-12-11 | E-GEOD-62171 | biostudies-arrayexpress
ProteomicsIdentification of a 144-amino-acid Scaffold Protein for Extracellular Vesicle Engineering
Extracellular vesicles (EVs) have emerged as promising drug-delivery vehicles. Genetic engineering of a membrane-bound, EV-sorting scaffold protein empowers these cell-borne nanosized vesicles by installing targeting moieties on the surface and enriching therapeutic cargo in the lumen. However, the ...
ORGANISM(S): Homo sapiens (Human) 
2026-04-27 | PXD057965 | Pride
Expi293f-evs Lc-s/ms 
ProteomicsIdentification of BRCA2-DSS1 new partner HELZ
R-loops are dynamic three-stranded nucleic acid structures that regulate genome function but can threaten genome stability if not properly resolved. BRCA2, a key player in homologous recombination (HR), also regulates R-loops, though the mechanisms remain unclear. To uncover novel R-loop regulators,...
ORGANISM(S): Homo sapiens (Human) 
2025-12-30 | PXD066766 | Pride
Hela Biotinid-dss1 Brca2 Helz 
MetabolomicsProfiling the metabolome of uterine fluid for early detection of ovarian cancer

Ovarian cancer (OC) causes high mortality in women because of ineffective biomarkers for early diagnosis. Here, we perform metabolomics analysis on an initial training set of uterine fluid from 96 gynecological patients. A seven-metabolite-marker panel consisting of vanillylmandelic acid, norepin...

2023-03-06 | MTBLS4861 | MetaboLights
ProteomicsInvestigating the Quantitative Proteomics of TMT Phosphorylation in Ningxia Wolfberry under Diverse Concentrations of Salt Stress: Unveiling Molecular Mechanisms and Implications
The experimental results revealed 2727 phosphorylated proteins, 5258 phosphorylated peptides and 5096 phosphorylation sites, which included 5252 quantifiable phosphorylated peptides and 5091 quantifiable phosphorylation sites on 2725 quantifiable modified proteins
ORGANISM(S): Lycium Barbarum 
2024-12-10 | PXD058720 |
ProteomicsPlasma proteomic and metabolomic signatures of B-ALL patients during CAR-T cell therapy
The study aimed to assess plasma proteomic and metabolomic profiling in patients with B-ALL during humanized anti-CD19-CAR-T cell therapy
ORGANISM(S): Homo Sapiens 
2023-02-24 | PXD040366 |
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