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TranscriptomicsGene expression after transfection of IGF-II specific siRNAs
Total RNA was isolated from HuH-7 cells after transfection of IGF-II specific siRNAs. Gene expression profiling was performed using the Affymetrix Human Genome U133A 2.0 Arrays. The raw data were analysed using mixed model ANOVA. Keywords: transfection with siRNA Cells transfected with two independe...
ORGANISM(S): Homo sapiens 
2010-05-25 | E-GEOD-8714 | biostudies-arrayexpress
ProteomicsMitochondria-related gene and protein changes in craniosynostosis: integrated transcriptomics and Fgfr2C361Y/+ cranial suture proteomics
This project maps mitochondria-associated molecular changes in craniosynostosis by integrating public human transcriptomes and by generating proteomic data from a genetically defined mouse model. Differential expression signals were intersected with the MitoCarta 3.0 inventory to prioritize mitochon...
ORGANISM(S): Mus Musculus 
2026-01-09 | PXD072912 |
TranscriptomicsCo-activator function of RIP140 for NFκB/p65-dependent cytokine gene
High- and low-grade inflammatory responses represent a hallmark of numerous pathologies such as sepsis and bacterial infection or insulin resistance and obesity, respectively. Here we describe an unexpected co-activator function of receptor interacting protein (RIP) 140 for nuclear factor (NF) kB, a...
ORGANISM(S): Mus musculus 
2010-05-22 | E-GEOD-10386 | biostudies-arrayexpress
TranscriptomicsTwo Supporting Factors Greatly Improve the Efficiency of Human iPS Cell Generation
Human fibroblasts can be induced into pluripotent stem cells (iPS cells), but the reprogramming efficiency is quite low. Here, we screened a panel of candidate factors in the presence of OCT4, SOX2, KLF4 and c-MYC in an effort to improve the reprogramming efficiency from human adult fibroblasts. We ...
ORGANISM(S): Homo sapiens 
2008-11-06 | E-GEOD-12922 | biostudies-arrayexpress
ProteomicsEnergy sensor AMPK gamma regulates translation via phosphatase PPP6C independent of AMPK alpha
In this project, SILAC-based quantitative proteomics approach was applied for phosphoproteomics analysis. The light samples were treated with ddH2O as control group, and the medium samples labeled by 2D2 of lysine (K4) and 13C6 of arginine (R6) were treated with 2DG, while the heavy samples labeled ...
ORGANISM(S): Homo Sapiens 
2022-11-08 | PXD038034 |
ProteomicsProteomic analysis reveals key differences between squamous cell carcinomas and adenocarcinomas across multiple tissues
To explore the biological insights into squamous cell carcinoma (SCC) derived from different organs, we reported a deep proteomic analysis of 333 SCCs of 17 organs and 69 adenocarcinomas (ACs) of 7 organs. Proteomic comparison between pan-SCCs and pan-ACs identifies distinguishable pivotal pathways,...
ORGANISM(S): Homo Sapiens 
2022-05-19 | PXD033794 |
UnknownComparison of the Oral Calcimimetics Evocalcet and Cinacalcet in East Asian Patients on Hemodialysis with Secondary Hyperparathyroidism.
Not available
S-EPMC10658267 | biostudies-literature
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