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MetabolomicsMechanism of interventional effect and targets of Zhuyu Pill in regulating and suppressing colitis and cholestasis

Zhuyu pill (ZYP) is a traditional Chinese medicine prescription composed of two drugs, Coptis chinensis Franch. and Tetradium ruticarpum (A. Jussieu) T. G. Hartley, and is commonly used in the clinical treatment of diseases of the digestive system. However, the mechanism underly...

2022-11-02 | MTBLS4980 | MetaboLights
MetabolomicsTubular insulin-induced gene 1 deficiency promotes NAD+ consumption and exacerbates kidney fibrosis

Profibrotic proximal tubular (PT) were identified as a unique phenotype of PTCs in renal fibrosis by single-cell RNA sequencing (scRNA-seq). Controlling the process of renal fibrosis requires understanding how to manage the S1 subset's branch to the S3 subset rather than to the profibrotic PT sub...

2024-05-28 | MTBLS9985 | MetaboLights
UnknownMoisture as a key factor alleviating low-temperature stress: Effects of hydrothermal conditions on maize emergence
Not available
S-EPMC12928403 | biostudies-literature
Genomicsena-DATASET-BGI-18-06-2015-05:57:10:511-19 - samples
We sequenced 205 patients who were suffering NSCLC with Exome sequencing method.
EGAD00001001398 | EGA
Genomicsena-DATASET-BGI-18-06-2015-04:55:13:301-17 - samples
We sequenced 292 patients who were suffering NSCLC with Whole genome sequencing or Exome sequencing method.
EGAD00001001397 | EGA
GenomicsFrequent alterations in cytoskeleton remodeling genes in primary and metastatic Chinese lung adenocarcinomas
The landscape of genetic alterations in lung adenocarcinoma derived from Asian patients is largely uncharacterized. Here we present an integrated genomic and transcriptomic analysis of 335 primary lung adenocarcinomas and 35 corresponding lymph node metastases from Chinese patients. Altogether 13 si...
EGAS00001000982 | EGA
GenomicsBGI Data Access Committee
Data Access Committee EGAC00001000177
EGAC00001000177 | EGA
ProteomicsMitochondria-related gene and protein changes in craniosynostosis: integrated transcriptomics and Fgfr2C361Y/+ cranial suture proteomics
This project maps mitochondria-associated molecular changes in craniosynostosis by integrating public human transcriptomes and by generating proteomic data from a genetically defined mouse model. Differential expression signals were intersected with the MitoCarta 3.0 inventory to prioritize mitochon...
ORGANISM(S): Mus Musculus 
2026-01-09 | PXD072912 |
ProteomicsS-nitrosylated cysteine residues identification in Staphylococcus aureus XN108
Staphylococcus aureus is a major human pathogen that causes diverse severe infections. The emergence of multi-drug resistance has caused S. aureus infection a global concern, especially resistance to vancomycin, a drug of last resort. A growing body of research focuses on the resistance mechanisms a...
ORGANISM(S): Staphylococcus Aureus 
2023-03-27 | PXD041143 |
ProteomicsResearch on the mechanism by which cancer-associated fibroblasts (CAFs) promote EGFR-TKI resistance in non-small cell lung cancer (NSCLC) via secretory proteins
Resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) remains a major clinical challenge in the targeted therapy of non-small cell lung cancer (NSCLC), yet its underlying mechanisms are poorly understood. The tumor microenvironment (TME), which provides a supportive n...
ORGANISM(S): Homo Sapiens 
2025-05-26 | PXD064318 |
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