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ProteomicsHMGB2 promote ESCC tumorigenesis and predict neoadjuvant therapy response
Recent studies have demonstrated that chronic stress can enhance the development of multiple human diseases, including cancer. However, the role of chronic stress in esophageal carcinogenesis and its underlying molecular mechanisms remain unclear. This study uncovered that dysregulated cholesterol m...
ORGANISM(S): Mus Musculus 
2025-01-09 | PXD059616 |
ProteomicsChronic stress-induced cholesterol metabolism abnormalities promote ESCC tumorigenesis and predict neoadjuvant therapy response
chronic stress activates the GCR-HMGB2-LDLR axis via cortisol release, leading to abnormal cholesterol metabolism and ultimately promoting esophageal carcinogenesis
ORGANISM(S): Homo Sapiens 
2025-01-09 | PXD059578 |
ProteomicsThe subcortical maternal complex modulates the cell cycle during early mammalian embryogenesis via 14-3-3
The subcortical maternal complex (SCMC) is essential for the maintenance of female fertility in mammals. Most pathogenic mutations in SCMC-encoding genes result in female reproductive failure characterized by early embryonic arrest. Assembled in oocytes, the SCMC maintains the normal cleavage of ear...
ORGANISM(S): Mus Musculus Spodoptera Frugiperda 
PXD055498 |
ProteomicsProteogenomic landscape of the Esophageal Squamous Cell Cancer reveals the lipid droplet formation process as a novel therapeutic target
The integrated proteogenomic analysis revealed proteomic characteristics associated with genomic variants and clinical features including arm or focal amplifications, SNV mutations, tumor size, lymph node metastasis, smoking history.
ORGANISM(S): Homo Sapiens 
2025-03-24 | PXD062163 |
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