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ProteomicsProteomics coupled transcriptomics reveals lipopolysaccharide inhibiting peroxisome proliferator-activated receptors signalling pathway to reduce lipid droplets accumulation in mouse liver
Lipid droplets (LDs) are multifunctional organelles consisting of a central compartment of non-polar lipids shielded from the cytoplasm by a phospholipid monolayer. The excessive accumulation of lipid droplets in cells is closely related to the development and progression of many diseases in humans ...
ORGANISM(S): Mus Musculus 
2023-01-27 | PXD039724 |
ProteomicsProteomics reveals the ribosome signaling pathway promoting prostate cancer progression and correlating with poor prognosis
Through digital rectal examinations and routine prostate-specific antigen (PSA) screening, early treatment of prostate cancer has become possible. However, prostate cancer is a complex and heterogeneous disease. In many patients, cancer cells can invade adjacent tissues and metastasize to other tiss...
ORGANISM(S): Homo Sapiens 
2021-09-05 | PXD028211 |
ProteomicsProteomics reveals the potential mechanism of Mrps35 controlling Listeria intracellular proliferation in macrophages
We performed the comprehensive proteomics to analyze the dynamic expression landscape of wild type and Mrps35 Knockdown Raw264.7 cells by Listeria infection over 6h. Based on the results of mass spectrometry, we presented a wide variety of hypotheses about the mechanism of Mrps35 controlling the Lis...
ORGANISM(S): Mus Musculus 
2020-10-22 | PXD022127 |
UnknownBlack TiO2 nanoprobe-mediated mild phototherapy reduces intracellular lipid levels in atherosclerotic foam cells via cholesterol regulation pathways instead of apoptosis.
Not available
S-EPMC8958315 | biostudies-literature
UnknownLow-dose hypomethylating agents cooperate with ferroptosis inducers to enhance ferroptosis by regulating the DNA methylation-mediated MAGEA6-AMPK-SLC7A11-GPX4 signaling pathway in acute myeloid leukemia.
Not available
S-EPMC10877917 | biostudies-literature
ProteomicsProteome-wide identification lncRNA CCAT1 directly binding proteins by RAP-MS
We purify and identify CCAT1 binding proteins by RAP-MS. As a result, we identified out more than 600 CCAT1 binding proteins and more than 60% of them are RNA binding proteins recorded by RBPs database EuRBPDB. Among the identified CCAT1 binding proteins, Vimentin is a crucial protein. Additionally,...
ORGANISM(S): Homo Sapiens 
2020-11-26 | PXD022774 |
ProteomicsQuantitative proteomics reveals the crucial roles of Cathepsin D in bacterial infections
Bacterial resistance has become more and more widespread which seriously threatens human life and health. Therefore, using the natural immune system of host to kill bacteria is particularly fascinating. Here, using mass spectrometry analyses, we depicted the dynamic expression landscape of mitochond...
ORGANISM(S): Mus Musculus 
2020-05-13 | PXD016938 |
ProteomicsThe Dynll1-Cox4il Complex Regulates Intracellular Pathogen Clearance via Release of Mitochondrial Reactive Oxygen Species
Cellular membrane proteins are a critical part of the host defense mechanisms against infection and intracellular survival of Listeria monocytogenes. The complex spatiotemporal regulation of bacterial infection by various membrane proteins has been challenging to study. Here, using mass spectrometry...
ORGANISM(S): Mus Musculus 
2020-02-17 | PXD016452 |
UnknownMolecular signatures of major depression.
Not available
S-EPMC4425463 | biostudies-literature
UnknownThe influence of coronavirus disease 2019 on emergency department visits in Nanjing, China: A multicentre cross-sectional study.
Not available
S-EPMC7415345 | biostudies-literature
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