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TranscriptomicsIdentification and Characterization of the Mammalian Nuclear RNA N6-Adenosine Methyltransferase Core Complex
N6-methyladenosine (m6A) is the most prevalent internal modification found in mammalian messenger and non-coding RNAs. The discoveries of functionally significant demethylases that reverse this methylation as well as the recently revealed m6A distributions in mammalian transcriptomes strongly indica...
ORGANISM(S): Homo sapiens 
2013-11-29 | E-GEOD-46705 | biostudies-arrayexpress
ProteomicsTMT-based quantitative proteomic analyses provide insights into acquisition of embryogenic ability in Agapanthus praecox
Somatic embryogenesis (SE) is an ideal model for plant cell totipotency. Transition from somatic cells to embryonic cells is the key to SE. The poor frequency of embryonic callus (EC) induction has limited the application of SE in many plants, such as Agapanthus praecox. We performed large-scale, qu...
ORGANISM(S): Agapanthus Praecox 
2022-01-25 | PXD031207 |
UnknownThe impact of hypertensive disorders of pregnancy on perinatal outcomes in twin pregnancies: a national multi-center cohort study.
Not available
S-EPMC12486792 | biostudies-literature
UnknownSTAT4 activation by leukemia inhibitory factor confers a therapeutic effect on intestinal inflammation
Not available
S-SCDT-EMBOJ-2018-99595 | biostudies-other
ProteomicsStructural basis for the asymmetric binding of coactivator SRC1 to FXR-RXRα and allosteric communication within the complex
In this study, we employed an integrative approach to investigate the interaction between FXR-RXRα-DNA complex and the entire coactivator SRC1-NRID (nuclear receptor interaction domain). We constructed a multi-domain model of FXR-RXRα-DNA, highlighting the interface between FXR-DBD and LBD. Using HD...
ORGANISM(S): Homo Sapiens 
2025-02-08 | PXD060593 |
ProteomicsProteomic and phosphoproteomic profiling of original, Delta, or Omicron strain SARS-CoV-2-infected lung of rhesus macaque
The Omicron variant, mutated from the original SARS-CoV-2 strain, is still circulating worldwide. We performed LC-MS based proteome and phosphoproteome analysis using lung tissues separated from rhesus monkeys, which were infected with Omicron, the original virus or one of the VOCs, the Delta varian...
ORGANISM(S): Macaca Mulatta 
2023-12-12 | PXD047779 |
ProteomicsThe data of protein expression of hMSCs in Soft, Medium and Stiff group
After treated with different stiffness and macrophage paracrine signals at the same stiffness for 3 days, MSCs were harvested for proteomic analysis. The label-free quantification (LFQ) based proteomic analysis was performed for global protein expressions.
ORGANISM(S): Homo Sapiens 
2022-07-21 | PXD035511 |
ProteomicsProteomic analysis reveals key differences between squamous cell carcinomas and adenocarcinomas across multiple tissues
To explore the biological insights into squamous cell carcinoma (SCC) derived from different organs, we reported a deep proteomic analysis of 333 SCCs of 17 organs and 69 adenocarcinomas (ACs) of 7 organs. Proteomic comparison between pan-SCCs and pan-ACs identifies distinguishable pivotal pathways,...
ORGANISM(S): Homo Sapiens 
2022-05-19 | PXD033794 |
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