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GenomicsGenome-wide survey of YY1 targets in C2C12 cells by High-throughput sequencing
By applying ChIP-seq, we generated genome-wide maps of YY1 in skeletal myoblasts and myotubes. We found that YY1 binds to 1820 confident target with a large portion residing in the intergenic regions. In addition, YY1 was found to activate many loci, and there is no significant overlap between YY1 a...
ORGANISM(S): Mus musculus 
2013-08-15 | E-GEOD-45875 | biostudies-arrayexpress
GenomicsYy1 activity in mouse embryonic stem cells
This SuperSeries is composed of the following subset Series: GSE31784: Expression changes in Yy1 knock down mouse embryonic stem cells GSE31785: Yy1 occupancy of mouse ES cell genome Refer to individual Series
ORGANISM(S): Mus musculus 
2012-01-04 | E-GEOD-31786 | biostudies-arrayexpress
TranscriptomicsBrown Adipose YY1 Deficiency Activates Expression of Secreted Proteins Linked to Energy Expenditure and Prevents Diet-Induced Obesity [BAT]
Analysis of brown adipose tissue from Yin Yang 1 (YY1) brown fat specific knockout mice fed a high fat diet for 3 months. YY1 deficiency in brown adipose tissue leads to strong thermogenic deficiency. The goal was to identify the genes controlled by YY1 responsible of brown fat defective function. C...
ORGANISM(S): Mus musculus 
2015-11-10 | E-GEOD-68429 | biostudies-arrayexpress
GenomicsEvolutionary comparison of CTCF and YY1 binding in primate lymphoblastoid cell lines
We performed an evolutionary comparison of the binding of the TF CTCF in human, chimpanzee, gorilla, orang-utan, macaque, baboon and marmoset using lymphoblastoid cell lines (LCLs). We also probes YY1 binding in human, chimpanzee, orang-utan and baboon LCLs as well as human and mouse liver.
ORGANISM(S): Pan troglodytes 
2013-11-20 | E-MTAB-1511 | biostudies-arrayexpress
GenomicsYy1 occupancy of mouse ES cell genome
These data include the genome wide location analyses of Yy1 by bioChIPs of Fbio-Yy1. Streptavidin precipitation of formaldehyde cross-linked chromatin prepared from Fbio-Yy1 and control expressing mouse ES cells
ORGANISM(S): Mus musculus 
2012-01-04 | E-GEOD-31785 | biostudies-arrayexpress
TranscriptomicsBrown Adipose YY1 Deficiency Activates Expression of Secreted Proteins Linked to Energy Expenditure and Prevents Diet-Induced Obesity [IWAT]
Analysis of subcutaneous adipose tissue (IWAT) from Yin Yang 1 brown fat specific knockout mice fed a high fat diet for 2 weeks. The goal was to identify a gene signature of IWAT browning in YY1 mutant mice. Control mice YY1flox/flox versus YY1flox/flox; Ucp1Cre were fed a high fat diet for 2 weeks
ORGANISM(S): Mus musculus 
2015-11-10 | E-GEOD-68382 | biostudies-arrayexpress
TranscriptomicsExpression changes in Yy1 knock down mouse embryonic stem cells
We have determined the global gene expression upon loss of function of the Yy1 transcription factor in mouse embryonic stem cells Total RNA was extracted from ES cells transiently transfected with yy1-specific or scrampled-control siRNA oligos 48 hr post-transfection.
ORGANISM(S): Mus musculus 
2012-01-04 | E-GEOD-31784 | biostudies-arrayexpress
GenomicsGordonia sp. YY1
Gordonia sp. YY1 Genome sequencing and assembly
PRJNA598818 | ENA
GenomicsNon-coding transcription within the Igh distal VH region at PAIR elements affects the 3D structure of the Igh locus in pro-B cells
Non-coding sense and antisense germline transcription within the immunoglobulin heavy chain locus precedes V(D)J recombination and has been proposed to be associated with Igh locus accessibility, although its precise role remains elusive. However, no global analysis of germline transcription through...
ORGANISM(S): Mus musculus 
2012-10-18 | E-GEOD-40822 | biostudies-arrayexpress
ProteomicsAssessing the dynamics and macromolecular interactions of the intrinsically disordered protein YY1
YY1 is a ubiquitously expressed, intrinsically disordered transcription factor involved in neural development. The oligomeric state of YY1 varies depending on the environment. These changes may alter its DNA binding ability and hence its transcriptional activity. In addition to its oligomeric state,...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD038431 | Pride
Yy1 Intrinsic disorder Foxp2 Dna binding Protein-protein interactions 
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