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ProteomicsChaFRAtip - Simple, scalable and ultra-sensitive tip-based identification of protease substrates
Enrichment of N-terminal peptides using HPLC-based ChaFRADIC and the novel tip-based ChaFRAtip method.
ORGANISM(S): Homo sapiens (Human) 
2018-01-24 | PXD006595 | Pride
N-terminomics 
ProteomicsReceptor tyrosine kinase dependent phospho-signaling networks determine cellular growth and survival in acute lymphoblastic leukemia
Receptor tyrosine kinase (RTK)-dependent signaling has been implicated in the pathogenesis of acute lymphoblastic leukemia (ALL) of childhood. However, the RTK-dependent signaling state and its interpretation with regard to biological behavior are often elusive. To decipher signaling circuits that l...
ORGANISM(S): Homo sapiens (Human) 
2019-11-22 | PRD000749 | Pride
Childhood all Receptor tyrosine kinase 
ProteomicsQuantitative proteomics of TNBC
Quantitative proteomics of triple negative breast cancer patient derived cell lines.
ORGANISM(S): Homo sapiens (Human) 
2019-11-25 | PXD013872 | Pride
Triple negative breast cancer 
ProteomicsConfident identification of citrullination and carbamylation assisted by peptide retention time prediction
We used 2D-LC-MS/MS methods to examine the impact of the biologically important PTM citrullination and its analogue carbamylation on peptide retention. Three first-dimension separation systems were evaluated: high-pH, HILIC and SCX, with the instrument interface separation happening at low-pH RP for...
ORGANISM(S): Bos Taurus (ncbitaxon:9913) Sus Scrofa (ncbitaxon:9823) Gallus Gallus (ncbitaxon:9031) Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
MSV000086214 | MassIVE
ProteomicsReduction-Free Thermolysin Digestion Enables Absolute Protein Quantitation in Plasma in 35 min from Sample to Result
We previously reported that the broad-specificity protease thermolysin yields reproducible, near-complete proteome digests within 1–2 min. Here we demonstrate rapid absolute protein quantitation in human plasma by combining reduction/alkylation-free thermolysin digestion on S-Trap cartridges with fu...
ORGANISM(S): Homo Sapiens 
PXD077823 | panorama
ProteomicsBroad-specificity enzymes enable fast and cost-effective digestion for in-depth proteomics and precise label free quantitation
We have devised fast and robust SP3- and STRAP-based protocols for the broad-specificity proteases subtilisin, proteinase K, and thermolysin. All three enzymes are remarkably fast, producing near-complete digests in 1-5 min, and cost 200-1000x less than proteomics-grade trypsin. Using FragPipe resol...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-11-29 | MSV000093532 | MassIVE
ProteomicsEstablishing personalized blood protein reference ranges using non-invasive microsampling and targeted proteomics: Implications for anti-doping strategies
To prevent doping practices in sports, the World Anti-Doping Agency implemented the Athlete Biological Passport (ABP) program, monitoring biological variables over time to indirectly reveal effects of doping rather than detect the doping substance or method itself. In the context of this program an...
ORGANISM(S): Homo Sapiens 
PXD048168 | panorama
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