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TranscriptomicsTranscription profiling of human lymphoblastic and myeloblastic leukemia samples with and without MLL rearrangements specific and lineage specific signatures
Gene expression analysis identified a MLL translocation-specific signature of differentially expressed genes discriminating ALL and AML with and without MLL rearrangements. Gene expression signatures of acute lymphoblastic and myeloblastic leukemia samples with and without MLL rearrangements were an...
ORGANISM(S): Homo sapiens 
2009-08-07 | E-GEOD-14062 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of leukemia samples prepared using different RNA isolation procedures
Microarray gene expression (MAGE) signatures allow insights into the transcriptional processes of leukemias and may evolve as a molecular diagnostic test. Introduction of MAGE into clinical practice of leukemia diagnosis will require comprehensive assessment of variation due to the methodologies. Fo...
ORGANISM(S): Homo sapiens 
2008-11-06 | E-GEOD-7757 | biostudies-arrayexpress
TranscriptomicsGene exprssion profile classification predicts clinical outcome in juvenile myelomonocytic leukemia
Gene expression analysis identified a specific signature of differentially expressed genes discriminating good and poor responders in JMML patients. Gene expression signatures were analyzed on two EWOG patient cohorts of pediatric JMML patients. Keywords: Expression data Class comparison between AM...
ORGANISM(S): Homo sapiens 
2009-12-31 | E-GEOD-14858 | biostudies-arrayexpress
TranscriptomicsMLL partner genes confer distinct biological and clinical signatures of pediatric AML, an AIEOP study
We retrospectively analyzed AML patients enrolled in the AIEOP since 2000, 42 patients with 11q23 rearrangement were analyzed by gene expression profile Gene expression analyses were performed to compare AML MLL partner genes (AF9, AF10, AF6, ENL, ELL, Septin 6, and AF1q) Keywords: Expression data ...
ORGANISM(S): Homo sapiens 
2011-04-21 | E-GEOD-19577 | biostudies-arrayexpress
TranscriptomicsLinking genomic lesions with minimal residual disease improves prognostic stratification in children with T-cell acute lymphoblastic leukaemia
GEP class prediction in association with CI-FISH (42 candidate genes) and patient MRD stratification Combined Interphase FISH (CI-FISH) for 42 candidate genes and Single Nucleotide Polymorphism (SNP) arrays were applied in a series of 51 T-ALL patients enrolled in Italy into the AIEOP-BFM ALL2000 pr...
ORGANISM(S): Homo sapiens 
2013-11-05 | E-GEOD-39816 | biostudies-arrayexpress
TranscriptomicsMLLT10 gene recombinations in pediatric T-Acute Lymphoblastic Leukemia
MLLT10, a 24 exons gene at 10p12, is known in leukemogenesis as partner of MLL or PICALM and recently NAP1L1. We identified HNRNPH1 and DDX3X, genes involved in RNA processing, as new MLLT10 partners in 2 cases of pediatric NOTCH1 positive T-ALL. HNRNPH1/5q35 encodes for a member of the ubiquitously...
ORGANISM(S): Homo sapiens 
2013-07-03 | E-GEOD-42765 | biostudies-arrayexpress
TranscriptomicsEarly Relapse in ALL is identified by Time To Leukemia in NOD/SCID mice and is characterized by a gene signature involving survival pathways
Gene expression analysis identified a specific signature of differentially expressed genes discriminating TTLshort and TTLlong phenotypes. Gene expression signatures of xenografted leukemia samples with different TTL phenotypes were analyzed on cohorts of pediatric BCP-ALL patients. Class compariso...
ORGANISM(S): Homo sapiens 
2011-02-10 | E-GEOD-13576 | biostudies-arrayexpress
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