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ProteomicsInteractome of the oncogenic deltaNp73alpha isoform in human papillomavirus 38 E6/E7-transformed keratinocytes
DeltaNp73alpha is a major oncogenic isoform of tumor suppressor p73. We report deltaNp73alpha protein binding partners in the organelle and cytoplasmic compartments of a cellular model consisting of human keratinocytes transformed by the E6 and E7 oncoproteins of the beta-HPV38 virus, which is assoc...
ORGANISM(S): Homo sapiens (Human) 
2024-12-06 | PXD056377 | Pride
Human keratinocytes Tumor suppressor p73 Interactome 
ProteomicsThe E2F4/p130 repressor complex cooperates with oncogenic Np73 to promote cell survival
Tumor suppressor p53 and its related proteins, p63 and p73, can be synthesized as multiple isoforms lacking part of the N- or C-terminal regions. Specifically, high expression of the Np73 isoform is notoriously associated with poor prognosis in cancer. Here, we have performed proteomics analysis of ...
ORGANISM(S): Homo sapiens (Human) 
2023-02-28 | PXD022947 | Pride
Cellular transformation E2f4 np73 Gene expression Protein-protein interactions P53 
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