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MetabolomicsA robust method for performing 1H-NMR lipidomics in embryonic zebrafish
The embryonic zebrafish is an ideal system for lipid analyses with relevance to many areas of bioscience research, including biomarkers and therapeutics. Research in this area has been hampered by difficulties in extracting, identifying and quantifying lipids. We employed 1H-NMR at 700MHz to profile...
2024-07-02 | MTBLS2396 | MetaboLights
MetabolomicsMyocardial-intrinsic defects underlie an Rbfox-mediated zebrafish model of hypoplastic left heart syndrome
Hypoplastic left heart syndrome (HLHS) is characterized by underdevelopment of left sided structures including the ventricle, valves, and aorta1. Although the mechanisms of disease pathogenesis remain elusive due to a paucity of candidate genes and animal models, prevailing paradigm suggests that HL...
2022-07-12 | MTBLS4176 | MetaboLights
OtherFunctional Mapping of the Zebrafish Early Embryo Proteome and Transcriptome
Data from PeptideAtlas, [[http://www.peptideatlas.org/PASS/PASS00444 PASS00444]]. Replicate: 2, experiment: G_120105_01_zebrafish_band3, file: folder summary. Published as part of J Proteome Res. 2014 Sep 17 . From the Abstract: {{i}} Zebrafish is a popular system for studying vertebrate developmen...
ORGANISM(S): Fish_e 
GPM32310004416 | GPMDB
ProteomicsZebrafish embryo_phosphorylation_18O labeling
The zebrafish (Danio rerio) is a popular animal model in studies of vertebrate development and organogenesis. Recent research has shown a similarity of approximately 70% between the human and zebrafish genomes and of 84% in human disease-causing genes, specifically. Zebrafish embryos have a number o...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2015-10-14 | PXD002232 | Pride
: zebrafish embryo 18o labeling Global phosphoproteome 
ProteomicsQuantitative proteomic profiling of estrogenic sexual endocrine perturbation in zebrafish embryos
Endocrine disruption (ED) can trigger far-reaching effects on environmental populations, justifying a refusal of market approval for chemicals with ED properties. For the assessment of ED effects on development and reproduction, regulatory decisions mostly rely on apical endpoints from in vivo testi...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2023-02-25 | PXD036868 | Pride
Zebrafish embryos Endocrine disruptors Lc-ms/ms 
ProteomicsQuantitative proteomic profiling of androgenic sexual endocrine perturbation in zebrafish embryos
Endocrine disruption (ED) can trigger far-reaching effects on environmental populations, justifying a refusal of market approval for chemicals with ED properties. For the assessment of ED effects on development and reproduction, regulatory decisions mostly rely on apical endpoints from in vivo testi...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2023-02-25 | PXD036875 | Pride
Zebrafish embryos Endocrine disruptors Lc-ms/ms 
ProteomicsQuantitative proteomic profiling of anti-estrogenic sexual endocrine perturbation in zebrafish embryos
Endocrine disruption (ED) can trigger far-reaching effects on environmental populations, justifying a refusal of market approval for chemicals with ED properties. For the assessment of ED effects on development and reproduction, regulatory decisions mostly rely on apical endpoints from in vivo testi...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2023-02-25 | PXD036869 | Pride
Zebrafish embryos Endocrine disruptors Lc-ms/ms 
ProteomicsQuantitative proteomic profiling of anti-androgenic sexual endocrine perturbation in zebrafish embryos
Endocrine disruption (ED) can trigger far-reaching effects on environmental populations, justifying a refusal of market approval for chemicals with ED properties. For the assessment of ED effects on development and reproduction, regulatory decisions mostly rely on apical endpoints from in vivo testi...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2023-02-25 | PXD036867 | Pride
Zebrafish embryos Endocrine disruptors Lc-ms/ms 
ProteomicsZebrafish Deyolking Survey - A Survey of the Impact of Deyolking on Biological Processes Covered by Shotgun Proteomic Analyses of Zebrafish Embryos
Deyolking, the removal of the most abundant protein from the zebrafish (Danio rerio) embryo, is a common technique for in-depth exploration of proteome-level changes in vivo due to various environmental stressors or pharmacological impacts during embryonic stage of development. However, the effect o...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2015-10-14 | PXD002124 | Pride
Bioinformatics Label-free proteomics Zebrafish Deyolking 
ProteomicsQuantitative proteome fin(ger)prints of triiodthyronin interference with the thyroid system in zebrafish embryos as 3R alternative in environmental hazard assessment
Endocrine disruption (ED) can trigger far-reaching effects on environmental populations, justifying a refusal of market approval for chemicals with ED properties. For the assessment of ED effects on the thyroid system, regulatory decisions mostly rely on amphibian studies. Here we present a rapid an...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2021-01-14 | PXD019111 | Pride
Thyroid hormone Endocrine disruption Zebrafish embryo Ecotoxicological testing Lc-ms/ms 
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