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MetabolomicsA robust method for performing 1H-NMR lipidomics in embryonic zebrafish
The embryonic zebrafish is an ideal system for lipid analyses with relevance to many areas of bioscience research, including biomarkers and therapeutics. Research in this area has been hampered by difficulties in extracting, identifying and quantifying lipids. We employed 1H-NMR at 700MHz to profile...
2024-07-02 | MTBLS2396 | MetaboLights
MetabolomicsMyocardial-intrinsic defects underlie an Rbfox-mediated zebrafish model of hypoplastic left heart syndrome
Hypoplastic left heart syndrome (HLHS) is characterized by underdevelopment of left sided structures including the ventricle, valves, and aorta1. Although the mechanisms of disease pathogenesis remain elusive due to a paucity of candidate genes and animal models, prevailing paradigm suggests that HL...
2022-07-12 | MTBLS4176 | MetaboLights
ProteomicsZebrafish embryo Kac - Global proteomic analysis of lysine acetylation in zebrafish (Danio rerio) embryos
Zebrafish (Danio rerio) model system have used widespread vertebrate investigations for genetic and cell biological analyses, and is suitable for small molecular screens such as chemical, toxicity and drug in order to use for human diseases and drug discovery . Recently, These powerful zebrafish mod...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2016-10-10 | PXD003455 | Pride
Embryos Ptms Lysine acetylation Zebrafish 
Proteomicszebrafish embryos proteome for slbp2 KO F3 and wild type
zebrafish embryos proteome for slbp2 KO F3 and wild type at 2.5hpf and 3.5hpf, three replicates for every sample. There are 12 samples in total. Then we analyse the different expressed genes and hope to find out clue which result in serious phenotype of slbp2 KO F3.
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2018-11-27 | PXD008614 | Pride
Slbp2 zebrafish embryos mbt 
ProteomicsQuantitative profiling of proteome extracted from zebrafish embryos exposed to different concentrations of the fungicide difenoconazole against untreated control groups.
In the present study OMICs analysis was employed to investigate the early molecular responses of zebrafish embryos to exposure to the fungicide difenoconazole. Difenoconazole, a sterol biosynthesis inhibitor according to Fungicide Resistance Action Committee (FRAC) classification, may also induce ad...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2024-01-02 | PXD045650 | Pride
Omics Proteome Fungicide Zebrafish embryos Lc-ms/ms 
ProteomicsQuantitative profiling of proteome extracted from zebrafish embryos exposed to different concentrations of the fungicide metalaxyl against untreated control groups.
In the present study OMICs analysis was employed to investigate the early molecular responses of zebrafish embryos to exposure to the fungicide metalaxyl. Metalaxyl, a nucleic acid metabolism inhibitor according to Fungicide Resistance Action Committee (FRAC) classification, may also induce adverse ...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2024-01-02 | PXD045444 | Pride
Omics Proteome Fungicide Zebrafish embryos Lc-ms/ms 
ProteomicsZebrafish Deyolking Survey - A Survey of the Impact of Deyolking on Biological Processes Covered by Shotgun Proteomic Analyses of Zebrafish Embryos
Deyolking, the removal of the most abundant protein from the zebrafish (Danio rerio) embryo, is a common technique for in-depth exploration of proteome-level changes in vivo due to various environmental stressors or pharmacological impacts during embryonic stage of development. However, the effect o...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2015-10-14 | PXD002124 | Pride
Bioinformatics Label-free proteomics Zebrafish Deyolking 
ProteomicsZebrafish embryo_phosphorylation_18O labeling
The zebrafish (Danio rerio) is a popular animal model in studies of vertebrate development and organogenesis. Recent research has shown a similarity of approximately 70% between the human and zebrafish genomes and of 84% in human disease-causing genes, specifically. Zebrafish embryos have a number o...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2015-10-14 | PXD002232 | Pride
: zebrafish embryo 18o labeling Global phosphoproteome 
TranscriptomicsTraf6 function in the innate immune response of zebrafish embryos
Transcriptional profiling of the zebrafish embryonic host response to a systemic bacterial infection with Salmonella typhimurium (strain SL1027); comparison between traf6 knock-down and control morpholino treated embryos. All infection experiments were performed using mixed egg clutches of ABxTL str...
ORGANISM(S): Danio rerio 
2010-08-01 | E-GEOD-21024 | biostudies-arrayexpress
TranscriptomicsEthanol alters microNA expression in zebrafish embryos
Prenatal exposure to ethanol leads to a myriad of developmental disorders known as fetal alcohol spectrum disorder, often characterized by growth and mental retardation, central nervous system damage and specific craniofacial dysmorphic features. Although the exact mechanisms of ethanol toxicity are...
ORGANISM(S): Danio rerio 
2012-06-17 | E-GEOD-32632 | biostudies-arrayexpress
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