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ProteomicsHDL Quality Features Revealed by Proteome-Lipidome Connectivity are Associated with Atherosclerotic Disease
The “quality” rather than “quantity” of lipoprotein particles is more relevant to cardiovascular diseases (CVD), since lipoprotein particles are highly heterogeneous. However, the targeted separation, detection, and exploration of the heterogeneous on omic-scale for lipoprotein remain challenging an...
ORGANISM(S): Homo Sapiens 
2020-02-15 | PXD017529 |
ProteomicsHDL quality feature revealed by proteome-lipidome connectivity are associated with atherosclerotic disease
Lipoprotein, especially high density lipoprotein (HDL) particles are composed of multiple heterogeneous subgroups containing various proteins and lipids. The molecular distribution among these subgroups is closely related to cardiovascular disease (CVD). Here, we established high-resolution proteomi...
ORGANISM(S): Oryctolagus Cuniculus Homo Sapiens 
2021-09-03 | PXD028209 |
MetabolomicsDT-109 ameliorates nonalcoholic steatohepatitis in nonhuman primates

Nonalcoholic steatohepatitis (NASH) prevalence is rising with no pharmacotherapy approved. A major hurdle in NASH drug development is the poor translatability of preclinical studies to safe/effective clinical outcomes, and recent failures highlight a need to identify new targetable pathways. Dysr...

2023-04-13 | MTBLS5005 | MetaboLights
ProteomicsModulation of Microbial Bile Acid Metabolism by DT-109 Ameliorates Nonalcoholic Steatohepatitis in Nonhuman Primates
Modulation of Microbial Bile Acid Metabolism by DT-109 Ameliorates Nonalcoholic Steatohepatitis in Nonhuman Primates
ORGANISM(S): Macaca Fascicularis Fascicularis 
2023-02-10 | PXD040009 |
ProteomicsInhibition of a novel CLK1-THRAP3-PPARγ axis improves insulin sensitivity
CLK1 plays a critical role in controlling energy expenditure through the CLK1-Thrap3-PPARγ axis.
ORGANISM(S): Homo Sapiens Mus Musculus 
2021-08-16 | PXD027958 |
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