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ProteomicspSILAC mass spectrometry reveals ZFP91 as novel IMiD dependent substrate of the CRL4CRBN ligase - PART 2
Thalidomide and its derivatives lenalidomide and pomalidomide (IMiDs) are effective treatments of hematologic malignancies. It was shown that IMiDs impart gain of function properties to the CUL4-RBX1-DDB1-CRBN (CRL4CRBN) ubiquitin ligase that enable binding, ubiquitination and degradation of key the...
ORGANISM(S): Homo sapiens (Human) 
2017-05-29 | PXD005857 | Pride
Imids Silac Lenalidomide Zfp91 
ProteomicspSILAC mass spectrometry reveals ZFP91 as novel IMiD dependent substrate of the CRL4CRBN ligase - PART 1
Thalidomide and its derivatives lenalidomide and pomalidomide (IMiDs) are effective treatments of hematologic malignancies. It was shown that IMiDs impart gain of function properties to the CUL4-RBX1-DDB1-CRBN (CRL4CRBN) ubiquitin ligase that enable binding, ubiquitination and degradation of key the...
ORGANISM(S): Homo sapiens (Human) 
2017-05-29 | PXD005849 | Pride
Imids Cereblon Lenalidomide Crbn Zfp91 
GenomicsZFP91 and IKZF1 Cooperatively Promote IMiD Resistance in T-Cell Lymphomas
ZFP91 and IKZF1 Cooperatively Promote IMiD Resistance in T-Cell Lymphomas
PRJNA723579 | ENA
TranscriptomicsZFP91 and IKZF1 Cooperatively Promote IMiD Resistance in T-Cell Lymphomas
The immunomodulatory (IMiD) agents, such as lenalidomide, are highly effective treatment for several B cell lymphomas but have poor efficacy in T cell lymphomas (TCLs). Here, we show that IKZF1 is a key drug target and vulnerability in lenalidomide sensitive TCL cells. However, TCLs are largely resi...
ORGANISM(S): Homo sapiens 
2022-04-21 | GSE172505 | GEO
UnknownZFP91-a newly described gene potentially involved in prostate pathology.
Not available
S-EPMC3973948 | biostudies-literature
UnknownZFP91 zinc finger protein expression pattern in normal tissues and cancers.
Not available
S-EPMC6396258 | biostudies-literature
UnknownZFP91 disturbs metabolic fitness and antitumor activity of tumor-infiltrating T cells.
Not available
S-EPMC8483753 | biostudies-literature
UnknownE3 ligase ZFP91 inhibits Hepatocellular Carcinoma Metabolism Reprogramming by regulating PKM splicing.
Not available
S-EPMC7392027 | biostudies-literature
UnknownGinsenoside Rg3 increases gemcitabine sensitivity of pancreatic adenocarcinoma via reducing ZFP91 mediated TSPYL2 destabilization.
Not available
S-EPMC9459078 | biostudies-literature
TranscriptomicspSILAC mass spectrometry reveals ZFP91 as novel IMiD dependent substrate of the CRL4CRBN ligase
Thalidomide and its derivatives lenalidomide and pomalidomide (IMiDs) are effective treatments of hematologic malignancies. It was shown that IMiDs impart gain of function properties to the CUL4-RBX1-DDB1-CRBN (CRL4CRBN) ubiquitin ligase that enable binding, ubiquitination and degradation of key the...
ORGANISM(S): Homo sapiens 
2017-03-01 | GSE94728 | GEO
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