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TranscriptomicsStudy of gene expression of mouse cMET experiments
We analyzed the molecular changes in a mouse c-MET over-expression model of hepatocellular carcinoma (HCC). FVB mice overexpressing human c-MET carried one copy of the LAP-tTa transgene (the liver-specific LAP promoter driving the Tet-VP16 transactivator) and one copy of the TRE-c-MET transgene (Tet...
ORGANISM(S): Mus musculus 
2011-08-14 | E-GEOD-25142 | biostudies-arrayexpress
TranscriptomicsSmall non-coding RNA expression in murine germ cells
In order to monitor the changes in small RNAs expression during mouse spermatogenesis. Type A spermatogonia, pachytene spermatocytes and round spermatids were isolated following collagenase treatment of testes and trypsin digestion of isolated seminiferous tubules using unit gravity sedimentation in...
ORGANISM(S): Mus musculus 
2011-06-10 | E-GEOD-24822 | biostudies-arrayexpress
TranscriptomicsStudy of gene expression of human liver Hepatocellular carcinoma
Hepatocellular carcinoma (HCC) affects millions of people worldwide and is a lethal malignancy for which there are no effective therapies. To identify prognostic gene markers for liver cancer, we conducted transcriptome profiling of frozen tissues (tumor and non-tumor) from 300 early-to-advanced sta...
ORGANISM(S): Homo sapiens 
2011-07-05 | E-GEOD-25097 | biostudies-arrayexpress
TranscriptomicsFGF2-regulated gene expression in cultured mouse spermatogonial stem cells
Transcriptional profiling of mouse spermatogonial stem cells (SSCs) comparing control untreated SSCs with SSCs with exogenous FGF2 withdrawn and FGFR inhibitor SU5402 supplemented (-F+S). Results provide insight into the mechanisms of FGF2-supported in vitro self-renewal of SSCs. Two-condition exper...
ORGANISM(S): Mus musculus 
2010-08-01 | E-GEOD-21294 | biostudies-arrayexpress
Transcriptomicssmall RNA deep-sequencing of mature sperm, testis and uterus in mice
In order to discover novel small RNAs expressed in mature sperm, we isolated mature sperm from mouse cauda epididymis, comparing with data from adult tesis and uterus. The small RNA fraction (18-40nt) was cloned and sequenced from total RNA of mature sperm, testis and uterus of mice. RNAs extracted ...
ORGANISM(S): Mus musculus 
2013-01-31 | E-GEOD-38702 | biostudies-arrayexpress
TranscriptomicsSmall non-coding RNA expression in mouse elongated spermatids
In order to discover novel small RNAs expressed in elongated spermatids, we isolated elongated spermatids from mouse testis. The small RNA fraction (18-40nt) was cloned and sequenced from total RNA. RNAs extracted from elongated spermatids were used for high throughput sequencing analysis
ORGANISM(S): Mus musculus 
2013-01-31 | E-GEOD-40397 | biostudies-arrayexpress
TranscriptomicsmiR-122 as a Regulator of Mitochondrial Metabolic Gene Network in Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is the leading cause of cancer-related deaths worldwide, reflecting the need for a better understanding of hepatocarcinogenesis. In this study, we examined the genome-wide expression profiles of both miRNAs and mRNAs from paired tumor and adjacent non-tumor tissues fro...
ORGANISM(S): Homo sapiens 
2010-06-09 | E-GEOD-22058 | biostudies-arrayexpress
TranscriptomicsmRNA expression of 131 cancer cell lines
131 human cancer cell lines' mRNA expression profiles have been characterized. Keywords: Cell Line Comparison mRNA samples obtained from 131 human cancer cell lines were hybridized to Agilent Human 3.0 A1 arrays and gene expression (mlratio) was measured relative to a common reference RNA pool (Hum...
ORGANISM(S): Homo sapiens 
2010-06-25 | E-GEOD-13598 | biostudies-arrayexpress
TranscriptomicsAdult_mouse_testis_CREM_ChIP_chip
Germ cells from adult mouse testes were isolated and ChIPed by CREM antibody. The purpose is to identify potential CREM targets during spermatogenesis. The CREM antibody ChIPed DNA segments were labeled with Cy5 and goat IgG ChIPed segments were labeled with Cy3 as control. No duplicates were design...
ORGANISM(S): Mus musculus 
2010-10-13 | E-GEOD-24623 | biostudies-arrayexpress
TranscriptomicsProfiling of Human Adipose Tissue and Effect of Sibutramine on Gene Expression
We analyzed the expression of 23,653 transcripts in the adipose tissue of 19 individuals treated with Sibutramine Keywords: sibutramine effect 157 adipose tissue samples from 19 individuals treated with sibutramin as well as placebo were profiled for gene expression.
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-10545 | biostudies-arrayexpress
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