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MetabolomicsAbsolute quantification of serum cytokines and metabolome reveals the glycylproline regulating antibody-fading in convalescent COVID-19 patients

The COVID-19 pandemic has incurred tremendous costs worldwide and is still threatening public health in the 'new normal'. The association between neutralizing antibody levels and metabolic alterations in convalescent patients with COVID-19 is still poorly understood. In the present work, we condu...

2024-08-26 | MTBLS3305 | MetaboLights
ProteomicsOligodendrocyte precursor cell-specific blocking of low glucose-induced activation of AMPK ensures myelination and remyelination
In this study, we screening the main types of cerebral cortex cells for glucose sensing and have find that AMPK is not activated in OPCs. We further discover that aldolase C (ALDOC) is acetylated at K14 in OPCs. Expression of ALDOC-K14R, with the acetylation lysine residues changed to arginine, rend...
ORGANISM(S): Rattus Rattus Homo Sapiens 
PXD067336 |
ProteomicsLow-dose metformin targets the lysosome-AMPK pathway through PEN2
Metformin is the most prescribed anti-diabetic medicine, and has also been shown to have other various benefits, such as anti-aging and anti-cancer effects. For clinical doses of metformin, it is known that AMPK plays a major role; however, the direct molecular target of metformin remains unclear. H...
ORGANISM(S): Homo Sapiens Mus Musculus 
2021-12-01 | PXD030090 |
ProteomicsLow glucose metabolite 3-phosphoglycerate switches PHGDH from serine synthesis to p53 activation to control cell fate
This project identified the interacting proteins of p53 under glucose starvation in HEK293 cells.
ORGANISM(S): Homo Sapiens 
PXD041361 |
ProteomicsLithocholic acid targets TULP3-Sirtuins to deacetylate v-ATPase and activate AMPK
Lithocholic acid (LCA), accumulated in mammals during calorie restriction (CR), can activate AMP-activated protein kinase (AMPK) and slow down ageing1. However, how LCA is signalled to activate AMPK and elicit the biological effects is unclear. Here, we show that LCA can enhance the activity of sirt...
ORGANISM(S): Homo Sapiens Mus Musculus 
PXD056134 |
ProteomicsThe aldolase inhibitor aldometanib mimics glucose starvation to activate lysosomal AMPK
The activity of 5’-adenosine monophosphate-activated protein kinase (AMPK) is inversely correlated with the cellular availability of glucose. When glucose levels are low, the glycolytic enzyme aldolase is not bound to fructose-1,6-bisphosphate (FBP) and, instead, signals to activate lysosomal AMPK. ...
ORGANISM(S): Oryctolagus Cuniculus 
2022-08-10 | PXD035968 |
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