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UnknownTargeting CD30L in B-cell non-Hodgkin lymphoma: novel peptide conjugates and their therapeutic potential.
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S-EPMC12228221 | biostudies-literature
ProteomicsAffinity purification of TRMT6/61A protein complexes
In order to identify the molecular mechanism leading to the increase of TRMT6/61A complex in aged HSCs, we purified proteins interacting with TRMT6 and TRMT61A via affinity purification. HEK293T cells stably expressing SFB-tagged TRMT6 or SFB-TRMT61A were lysed in NETN buffer (20 mM Tris-HCl [pH 8.0...
ORGANISM(S): Homo Sapiens 
2023-11-30 | PXD047430 |
ProteomicsChemoproteomic Mapping of the Glycolytic Targetome in Cancer Cells
we report a Target Responsive Accessibility Profiling (TRAP) approach for the global and quantitative analysis of glycolytic metabolites targetome in native cancer cell milieu.
ORGANISM(S): Homo Sapiens 
2020-11-17 | PXD022568 |
ProteomicsLactylation-stabilized NOL6 promotes colorectal cancer progression via recruiting STAMBP to deubiquitinate YY1 and upregulate MYC transcription
Colorectal cancer (CRC) represents a significant menace to human health, but its molecular pathogenesis remains unclear. Herein, we explored the functional role of Spindle and Nucleolar Protein 6 (NOL6) in CRC progression. In this study, we found NOL6 was significantly overexpressed in CRC tissues, ...
ORGANISM(S): Homo Sapiens 
2025-10-22 | PXD069802 |
ProteomicsCyclic immonium ion of lactyllysine reveals widespread lactylation in the human proteome
Here we employed a non-enzymatic chemical labeling approach to introduce lactylation on lysine residues of model peptides and proteins. Tandem MS acquisition of lactylated peptide carriers on different MS platforms unequivocally led us to note an intense peak corresponding to the “cyclic” immonium ...
ORGANISM(S): Homo Sapiens 
2021-09-15 | PXD028488 |
ProteomicsComprehensive mass spectral libraries of human thyroid tissue and cells
We established deep-coverage thyroid-specific spectral libraries encompassing over 12,000 proteins, including samples from nine types of thyroid primary and lymph node metastases tissues and fifty thyroid cancer cell lines.
ORGANISM(S): Homo Sapiens 
2024-09-27 | PXD051051 |
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