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UnknownCaenorhabditis elegans neuronal regeneration is influenced by life stage, ephrin signaling, and synaptic branching.
We previously reported functional regeneration of Caenorhabditis elegans motor neurons after femtosecond laser axotomy. We report here that multiple neuronal types can regrow after laser axotomy using a variety of lasers. The precise pattern of regrowth varies with cell type, stage of animal, and po...
S-EPMC1975853 | biostudies-literature
UnknownVisual pigment-deficient cones survive and mediate visual signaling despite the lack of outer segments.
Rhodopsin and cone opsins are essential for light detection in vertebrate rods and cones, respectively. It is well established that rhodopsin is required for rod phototransduction, outer segment disk morphogenesis, and rod viability. However, the roles of cone opsins are less well understood. In thi...
S-EPMC8892328 | biostudies-literature
UnknownAsparagine endopeptidase cleaves α-synuclein and mediates pathologic activities in Parkinson's disease.
Aggregated forms of α-synuclein play a crucial role in the pathogenesis of synucleinopathies such as Parkinson's disease (PD). However, the molecular mechanisms underlying the pathogenic effects of α-synuclein are not completely understood. Here we show that asparagine endopeptidase (AEP) cleaves hu...
S-EPMC5871868 | biostudies-literature
UnknownRight ventricular systolic function is associated with health-related quality of life: a cross-sectional study in community-dwelling populations.

Background

Considerable evidence has been presented that heart and health-related quality of life are directly linked in patients with various diseases. This exploratory study investigated whether cardiac structure and function were associated with health-related quality of life in the gener...
S-EPMC8106091 | biostudies-literature
GenomicsGenome-Wide Association Studies in Upper Gastrointestinal Cancers (Asian)

This project aims to conduct genome-wide association studies (GWAS) in two anatomically different upper gastrointestinal (UGI) cancer sites in two populations with distinctly different disease rates and genetic profiles. One population has very high rates for both esophageal squamous cel...

phs000361.v1.p1 | EGA
UnknownMassively parallel in vivo Perturb-seq reveals cell-type-specific transcriptional networks in cortical development.
Leveraging AAVs' versatile tropism and labeling capacity, we expanded the scale of in vivo CRISPR screening with single-cell transcriptomic phenotyping across embryonic to adult brains and peripheral nervous systems. Through extensive tests of 86 vectors across AAV serotypes combined with a transpos...
S-EPMC11193654 | biostudies-literature
UnknownTranscription Elongation Machinery Is a Druggable Dependency and Potentiates Immunotherapy in Glioblastoma Stem Cells.
Glioblastoma (GBM) is the most lethal primary brain cancer characterized by therapeutic resistance, which is promoted by GBM stem cells (GSC). Here, we interrogated gene expression and whole-genome CRISPR/Cas9 screening in a large panel of patient-derived GSCs, differentiated GBM cells (DGC), and ne...
S-EPMC8831451 | biostudies-literature
UnknownManagement of regional citrate anticoagulation for continuous renal replacement therapy: guideline recommendations from Chinese emergency medical doctor consensus.
Continuous renal replacement therapy (CRRT) is widely used for treating critically-ill patients in the emergency department in China. Anticoagulant therapy is needed to prevent clotting in the extracorporeal circulation during CRRT. Regional citrate anticoagulation (RCA) has been shown to potentiall...
S-EPMC10226261 | biostudies-literature
Proteomicsthe function of RNA Binding Protrein in cancer
RNA Binding Protrein plays of vital imortance in cancer progression.
ORGANISM(S): Homo Sapiens 
2021-12-08 | PXD022776 |
UnknownDiagnostic accuracy of magnetically guided capsule endoscopy with a detachable string for detecting oesophagogastric varices in adults with cirrhosis: prospective multicentre study.

Objective

To evaluate the diagnostic accuracy and safety of using magnetically guided capsule endoscopy with a detachable string (ds-MCE) for detecting and grading oesophagogastric varices in adults with cirrhosis.

Design

Prospective multicentre diagnostic accuracy study.

Setting

S-EPMC10912951 | biostudies-literature
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