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UnknownChromosome-level genome assembly of the Stoliczka's Asian trident bat (Aselliscus stoliczkanus).
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S-EPMC10724287 | biostudies-literature
TranscriptomicsTargeted disruption of Hotair leads to homeotic transformation and de-repression of imprinted genes [Microarray Analysis]
Long noncoding RNAs (lncRNAs) are thought to be prevalent regulators of gene expression, but the consequences of lncRNA inactivation in vivo are mostly unknown. Here we show that targeted deletion of mouse Hotair lncRNA leads to de-repression of hundreds of genes, resulting in homeotic transformatio...
ORGANISM(S): Mus musculus 
2013-08-21 | E-GEOD-48004 | biostudies-arrayexpress
GenomicsTargeted disruption of Hotair leads to homeotic transformation and de-repression of imprinted genes [RNA-Seq, ChIP-Seq]
Long noncoding RNAs (lncRNAs) are thought to be prevalent regulators of gene expression, but the consequences of lncRNA inactivation in vivo are mostly unknown. Here we show that targeted deletion of mouse Hotair lncRNA leads to de-repression of hundreds of genes, resulting in homeotic transformatio...
ORGANISM(S): Mus musculus 
2013-08-21 | E-GEOD-48005 | biostudies-arrayexpress
ProteomicsIntegrated Proteomic Profiling of Aqueous Humor Reveals CDC42/RHOA-Mediated Pathogenic Mechanisms in nAMD and PDR
Neovascular AMD (nAMD) and proliferative diabetic retinopathy (PDR) are major blinding retinal diseases characterized by pathological angiogenesis. Using data-independent acquisition (DIA) proteomics, we analyzed aqueous humor from nAMD, PDR, and cataract control patients. Among 3186 identified prot...
ORGANISM(S): Homo Sapiens 
2025-09-09 | PXD068217 |
ProteomicsPrelamin A interacts with RIPK1 in ZMPSTE24-deficient cells
To understand the gain-of-toxicity of unprocessed prelamin A, we sought to identify the specific binding proteins of prelamin A that do not interact with mature lamin A. Because prelamin A is specifically localized to the nuclear envelope, we used ascorbate peroxidase 2 (APEX2)-based proximity label...
ORGANISM(S): Homo Sapiens 
2024-01-31 | PXD049033 |
ProteomicsSENP1 prevents steatohepatitis by suppressing RIPK1-driven apoptosis and inflammation
SENP1 deSUMOylates RIPK1 in TNF-R1 signaling complex (TNF-RSC), keeping RIPK1 in check. Loss of SENP1 leads to SUMOylation of RIPK1, which re-orchestrates TNF-RSC and modulates the ubiquitination patterns and activity of RIPK1.
ORGANISM(S): Mus Musculus 
2022-10-24 | PXD037648 |
ProteomicsProteomics reveals mitochondrial dysfunction in Lmna-/- mice hearts
We performed proteomics analysis on Lmna-/- hearts from mice at 2 weeks and 1 month of age to investigate the underlying mechanism by which LMNA deletion evokes DCM
ORGANISM(S): Mus Musculus 
2023-06-25 | PXD043270 |
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