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MetabolomicsChanges in L-phenylalanine concentration reflect and predict response to anti-PD-1 treatment combined with chemotherapy in patients with non-small cell lung cancer
Chemotherapy combined with checkpoint blockade antibodies targeting programmed cell death protein (PD-1) has achieved remarkable success in non-small cell lung cancer (NSCLC). However, few patients benefit from long-term treatment. Therefore, biomarkers capable of guiding the optimal therapeutic sel...
2025-06-16 | MTBLS11232 | MetaboLights
MetabolomicsDistinct metabolic profiling is correlated with bisexual flowers formation resulting from exogenous ethephon induction in melon (Cucumis melo L.)

Melon (Cucumis melo L.) is an agronomically important vegetable. Most cultivars of melon are andromonoecious and bisexual flowers only emerged from the leaf axil of lateral branches. However, the regulatory mechanism contributing to the occurrence of bisexual flowers were still obscure. ...

2022-03-10 | MTBLS2993 | MetaboLights
UnknownChidamide in Combination With DCAG With or Without Venetoclax for Relapsed/Refractory Acute Myeloid Leukemia.
Not available
S-EPMC11891779 | biostudies-literature
MetabolomicsUPLC-Q-TOF/MS-Based Plasma and Urine Metabolomics Contribute to the Diagnosis of Sepsis
In this study, we aimed to identify potential metabolic biomarkers that can improve the diagnostic accuracy of sepsis. Sixty-six patients including 30 septic and 36 nonsepsis patients from an intensive care unit were recruited. The global plasma and urine metabolomic profiles were determined by ultr...
2023-04-18 | MTBLS3505 | MetaboLights
MetabolomicsUltraperformance Liquid Chromatography Coupled with Quadrupole Time-of-Flight Mass Spectrometry-Based Metabolomics and Lipidomics Identify Biomarkers for Efficacy Evaluation of Mesalazine in a Dextran Sulfate Sodium-Induced Ulcerative Colitis Mouse Model
This study aims to identify biomarkers for evaluating the therapeutic efficacy of mesalazine on ulcerative colitis by metabolomics and lipidomics. A dextran sulfate sodium-induced mouse model was used. The disease status was assessed by a disease activity index, the TNF-α level of colon was measured...
2022-10-24 | MTBLS2111 | MetaboLights
ProteomicsIntegrative Multianalytical Model Based on Novel Plasma Protein Biomarkers for Distinguishing Lung Adenocarcinoma and Benign Pulmonary Nodules
Given the pressing clinical problem of making decision in diagnosis for subjects with pulmonary nodules, we aimed to discover novel plasma protein biomarkers for lung adenocarcinoma (LUAD) and benign pulmonary nodules (BPN), then develop an integrative multianalytical model to guide the clinical man...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD046731 | Pride
Differential diagnosis Integrative multianalytical model Lung adenocarcinoma Plasma proteomics Benign pulmonary nodules 
ProteomicsChlorogeni cacid compounds from sweetpotato (lpomoeabatatas L.) leaves facilitate megakaryocyte differentiationand thrombocytopoiesis via Pl3K/AkT pathway
Idiopathic thrombocytopenic purpura (lTP) is anautoimmune disorder characterized by antiplateletautoantibodies, thrombocytopenia, and bleeding. In thisstudy, a kind of active component, chlorogenic acidcompounds(CGAs)from sweetpotato leaves was isolatedby ionic liquids-ultrasound, which contains 6 i...
ORGANISM(S): Mus Musculus 
2024-08-15 | PXD054945 |
TranscriptomicsGene expression profiles during larval development for pearl oyster, Pinctada fucata
A microarray analysis has been employed to study the knowledge of different developmental stages and the related gene expression profiles of P.fucata. Our study focused on the global genes expression profiles of the fertilized egg, trochophore, D-shaped stage, umbonal stage, juvenile of P.fucata. Fe...
ORGANISM(S): Pinctada fucata 
2014-12-04 | E-GEOD-63824 | biostudies-arrayexpress
TranscriptomicsDevelopment of gene expression profiles for pearl oyster Pinctada fucata exposed in near-future ocean warming and acidification.
To elucidate how does the gene expression profiles of whole transcriptome of P.fucata response to acute and gradual seawater acidification and warming, and which genes or functional gene clusters are involved in the stress response to enviromental stressors, we have employed microarray as a tool to ...
ORGANISM(S): Pinctada fucata 
2014-05-02 | E-GEOD-57171 | biostudies-arrayexpress
UnknownClinical characteristics and prognostic factors of non-malignant pleural effusions in hospitalised patients: a retrospective cohort study.
Not available
S-EPMC11293410 | biostudies-literature
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