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Pretreated human follicular fluid was prepared for targeted metabolomics experiments. For this purpose, 12-point standard calibration curves in the respective range with reference material were measured, and the limit of detection (LOD) and limit of quantification (LOQ) for each neurotransmitter und...
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD031560 | Pride
The concentrations of twenty kinds of hormones in the follicular fluid were detected by high-performance liquid chromatography–mass spectrometry (HPLC-MS/MS). An Agilent 1200 series high-performance liquid chromatography (HPLC) instrument (Agilent, USA) was utilized. A PAL autosampler (CTC, Swiss) a...
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD031559 | Pride
LC3-associated phagocytosis (LAP) is critical in host defense against invading pathogens, but the molecular mechanism for LAP activation is still unclear. Here, we find programmed cell death 6 (PDCD6) as a negative regulator of LAP. PDCD6 deficiency in mice and macrophages induces enhanced bacterici...
ORGANISM(S): Homo sapiens (Human) 
2024-10-18 | PXD056047 | Pride
This study aims to investigate the neuroprotective effects of semaglutide in Diabetes-associated cognitive decline (DACD), while also exploring the underlying mechanisms targeting anti-oxidative effects.Methods: This study evaluated the antioxidant properties of semaglutide in a DACD model. To inves...
ORGANISM(S): Mus Musculus 
2024-10-21 | PXD056999 |
Platelets were isolated from C57BL6/J (C57) mice following established methodology detailed in our prior publication23. In brief, whole blood was collected via the inferior vena cava from C57BL/6J mice (aged 6–8 weeks) under anesthesia induced by 2.5% tribromoethanol (200 mg/kg). Then, an unbiased ...
ORGANISM(S): Mus Musculus 
2026-04-09 | PXD076844 |

The gut microbiome has emerged as a potential factor in cancer pathogenesis, but its role in non-functioning pituitary neuroendocrine tumors (NF-PitNETs) remains unclear. This study aimed to elucidate gut microbiome and metabolomic alterations in NF-PitNETs by comparing microbial diversity, patho...

2025-06-16 | MTBLS12328 | MetaboLights
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