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MetabolomicsGut microbiota production of trimethyl-5-aminovaleric acid reduces fatty acid oxidation and accelerates cardiac hypertrophy
Numerous studies found intestinal microbiota alterations which are thought to affect the development of various diseases through the production of gut-derived metabolites. However, the specific metabolites and their pathophysiological contribution to cardiac hypertrophy or heart failure progression ...
2021-12-08 | MTBLS3174 | MetaboLights
MetabolomicsDT-109 ameliorates nonalcoholic steatohepatitis in nonhuman primates

Nonalcoholic steatohepatitis (NASH) prevalence is rising with no pharmacotherapy approved. A major hurdle in NASH drug development is the poor translatability of preclinical studies to safe/effective clinical outcomes, and recent failures highlight a need to identify new targetable pathways. Dysr...

2023-04-13 | MTBLS5005 | MetaboLights
ProteomicsC1QBP mitochondrial interactome
The study of protein-protein interactions is an essential process to understand the biological functions of proteins and the underlying mechanisms. Co-immunoprecipitation coupled with mass spectrometry (CoIP-MS) is one of the most extensively used high-throughput techniques to discover novel protein...
ORGANISM(S): Homo Sapiens 
2015-11-04 | MSV000079369 | MassIVE
MetabolomicsIntegrated Multi-omics Analysis Identifies Diagnostic Biomarkers for Acute Coronary Syndrome in Type 2 Diabetes Mellitus Patients

Biomarkers for the early identification of acute coronary syndrome (ACS) risk remain inadequately investigated, particularly in patients with type 2 diabetes mellitus (T2DM), for whom timely clinical intervention may substantially enhance prognostic outcomes. The gut microbiota and serum metaboli...

2026-03-19 | MTBLS14087 | MetaboLights
ProteomicsKLF4-PFKFB3-driven glycolysis is essential for phenotypic switching of vascular smooth muscle cells
Vascular smooth muscle cells (VSMCs) within atherosclerotic lesions undergo a phenotypic switching in a KLF4-dependent manner. Glycolysis plays important roles in transdifferentiation of somatic cells, however, it is unclear whether and how KLF4 mediates the link between glycolytic switch and VSMCs ...
ORGANISM(S): Homo Sapiens 
2022-11-09 | PXD038057 |
ProteomicsDeep Multilayer Tissue Proteomics Identifies Molecular Networks in Alzheimer’s Disease Progression, human data
The molecular networks underlying Alzheimer’s disease (AD) are not well-defined. We present temporal profiling of >14,000 proteins and >34,000 phosphosites at the asymptomatic and symptomatic stages of AD, deep proteomics analysis of transgenic mouse models.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-10-17 | MSV000096123 | MassIVE
ProteomicsBacterial Protoplast-Derived Nanovesicles Carrying CRISPR Cas9 Tools Efficiently Re-educate Tumor-Associated Macrophages for Cancer Immunotherapy
we developed an in vivo CRISPR-Cas9 genome editing system that targets tumor-associated macrophages (TAMs) via bacterial protoplast-derived nanovesicles (NVs) decorated with a pH-responsive PEG conjugated polymer and galactosamine-conjugated ligand
ORGANISM(S): Escherichia Coli Bl21(de3) 
PXD045507 |
ProteomicsSelective identification of epigenetic regulators at methylated genomic sites by SelectID
Identification and quantification of biotinylated proteins enriched by the Sp-system at Chromosome 9 Satellite regions using TMT-labeled quantitative mass spectrometry
ORGANISM(S): Homo Sapiens 
2025-03-05 | PXD061483 |
ProteomicsValidation of α-satellite-associated regulators using the dCas9-TurboID system in HeLa cells
To validate whether the dCas9-TurboID system is applicable for proximity labeling at specific genomic regions, label-free mass spectrometry was employed to validate the satellite relative proteins that were enriched in the group of stable Hela cell line expressing sgAS.
ORGANISM(S): Homo Sapiens 
2025-03-05 | PXD061518 |
ProteomicsSelective identification of epigenetic regulators at methylated genomic sites
We applied SelectID coupled with the ultra-sensitive micro-DIA approach to enrich the associated proteins of Chromosome 9 satellite region and methylated LINE-1 elements.
ORGANISM(S): Homo Sapiens 
2025-03-08 | PXD061627 |
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